Efficacy and Safety of Low-Dose Dutasteride for Male Androgenic Alopecia: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Phase III Clinical Trial

January 2025 in “ Annals of Dermatology ”

Subin Lee, Jung Eun Kim, Bark‐Lynn Lew, Chang‐Hun Huh, J Kim, Ohsang Kwon, Moon‐Bum Kim, Yang Won Lee, Young Lee, Jin Park, Sangseok Kim, Do Young ‍Kim, Gwang Seong Choi, Hoon Kang

dutasteride androgenic alopecia hair growth erectile dysfunction AGA

Studysummary In this study, 0.2 mg dutasteride significantly improved hair growth in men with androgenetic alopecia compared to placebo over 24 weeks, showing similar efficacy to the higher 0.5 mg dose with a favorable safety profile.

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research 5-Alpha Reductase Inhibitors in Androgenetic Alopecia: Shifting Paradigms, Current Concepts, Comparative Efficacy, and Safety

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This review found that dutasteride is more potent than finasteride as a dual receptor dihydrotestosterone blocker for treating androgenetic alopecia and shares a similar safety profile in terms of fertility, teratogenicity, neurotoxicity, and hepatotoxicity.

The Efficacy and Safety of Dutasteride Compared with Finasteride in Treating Men with Androgenetic Alopecia: A Systematic Review and Meta-Analysis

research The Efficacy and Safety of Dutasteride Compared with Finasteride in Treating Men with Androgenetic Alopecia: A Systematic Review and Meta-Analysis

38 citations , February 2019 in “Clinical Interventions in Aging”

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5 citations , March 2017 in “Journal of Dermatology”

This survey reported that 37.6% of male AGA patients were satisfied with their treatments, with the highest satisfaction for 5-alpha-reductase inhibitors, and revealed differing perceptions between physicians and patients about AGA's impact on confidence and treatment involvement.

Superiority of Dutasteride Over Finasteride in Hair Regrowth and Reversal of Miniaturization in Men With Androgenetic Alopecia: A Randomized Controlled Open-Label, Evaluator-Blinded Study

research Superiority of Dutasteride Over Finasteride in Hair Regrowth and Reversal of Miniaturization in Men With Androgenetic Alopecia: A Randomized Controlled Open-Label, Evaluator-Blinded Study

33 citations , August 2016 in “Indian Journal of Dermatology, Venereology and Leprology”

In this study of men with androgenetic alopecia, dutasteride was shown to be more effective than finasteride in increasing hair count and reversing hair miniaturization over 24 weeks, with both treatments displaying similar side effect profiles.

research Long-Term Safety and Efficacy of Dutasteride in the Treatment of Male Patients with Androgenetic Alopecia

32 citations , February 2016 in “Journal of Dermatology”

This study found that in Japanese male patients with androgenetic alopecia, dutasteride 0.5 mg daily over 52 weeks was associated with improvements in hair growth and appearance, with reported adverse events mostly mild.

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This study found that dutasteride increased hair growth and restoration in men with androgenetic alopecia more effectively than finasteride and was well tolerated over 24 weeks.

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research Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla

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research Efficacy, Safety, and Tolerability of Dutasteride 0.5 mg Once Daily in Male Patients with Male Pattern Hair Loss: A Randomized, Double-Blind, Placebo-Controlled, Phase III Study

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research The Prevalence and Types of Androgenetic Alopecia in Korean Men and Women

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