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    Glossary Growth Factor Signaling

    process where proteins trigger cellular growth and repair

    Growth Factor Signaling refers to the process by which certain proteins, known as growth factors, bind to specific receptors on the surface of cells, triggering a cascade of biochemical reactions inside the cell. This signaling pathway is crucial for regulating various cellular activities, including growth, division, and differentiation, and plays a significant role in tissue repair and development. For example, in the context of hair growth, specific growth factors can stimulate hair follicle cells to enter the growth phase, promoting hair regeneration.

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    1. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019 · 136 citations
    2. 484 Transforming growth factor-β signaling-mediated wound healing is required hair follicle neogenesis Journal of Investigative Dermatology · 2024
    3. Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction Trends in Cell Biology · 2014 · 119 citations
    4. Mathematical Modeling and Inference of Epidermal Growth Factor-Induced Mitogen-Activated Protein Kinase Cell Signaling Pathways International Journal of Molecular Sciences · 2024 · 3 citations
    5. Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16 Stem Cells and Development · 2016 · 83 citations
    6. Epidermal Growth Factor Promotes Proliferation and Migration of Follicular Outer Root Sheath Cells via Wnt/β-Catenin Signaling Cellular physiology and biochemistry · 2016 · 43 citations
    7. Epidermal growth factor promotes proliferation of dermal papilla cells via Notch signaling pathway Biochimie · 2016 · 36 citations
    8. Astragalus membranaceus and Cinnamomum cassia Stimulate the Hair Follicle Differentiation-Related Growth Factor by the Wnt/β-Catenin Signaling Pathway Current Issues in Molecular Biology · 2023
    9. Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes Molecular and Cellular Biology · 2006 · 226 citations
    10. Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle The Journal of Cell Biology · 2005 · 53 citations
    11. Quercitrin Stimulates Hair Growth with Enhanced Expression of Growth Factors via Activation of MAPK/CREB Signaling Pathway Molecules · 2020 · 25 citations
    12. Nonanal Stimulates Growth Factors via Cyclic Adenosine Monophosphate (cAMP) Signaling in Human Hair Follicle Dermal Papilla Cells International Journal of Molecular Sciences · 2020 · 8 citations
    13. Activation of cAMP Signaling in Response to α-Phellandrene Promotes Vascular Endothelial Growth Factor Levels and Proliferation in Human Dermal Papilla Cells International journal of molecular sciences · 2022 · 6 citations
    14. Stromal Vascular Fraction and Platelet-Rich Plasma Upregulate Vascular Endothelial Growth Factor Expression to Promote Hair Growth via the Wnt/β-Catenin Signaling Pathway Nanoscience and Nanotechnology Letters · 2019 · 2 citations
    15. Urotensin II promotes the proliferation and secretion of vascular endothelial growth factor in rat dermal papilla cells by activating the Wnt-β-catenin signaling pathway Italian Journal of Medicine · 2023
    16. Platelet-derived growth factor signaling modulates adult hair follicle dermal stem cell maintenance and self-renewal npj Regenerative Medicine · 2017 · 37 citations
    17. An investigation of crosstalk between Wnt/β-catenin and transforming growth factor-β signaling in androgenetic alopecia Medicine · 2016 · 18 citations
    18. Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells 2007 · 66 citations
    19. Signaling by the Platelet-Derived Growth Factor Receptor Family 2009
    20. Protopanaxatirol type ginsenoside Re promotes cyclic growth of hair follicles via inhibiting transforming growth factor β signaling cascades Biochemical and Biophysical Research Communications · 2016 · 14 citations
    21. Corrections to “Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells” Journal of Investigative Dermatology · 2007
    22. Reductive Stress Selectively Disrupts Collagen Homeostasis and Modifies Growth Factor-independent Signaling Through the MAPK/Akt Pathway in Human Dermal Fibroblasts Molecular & cellular proteomics · 2019 · 9 citations
    23. Modulation of sonic hedgehog, patched and patched-2 expression by epidermal growth factor signaling in mouse hair follicle formation Medical Entomology and Zoology · 2000
    24. Millet seed oil activates β–catenin signaling and promotes hair growth Frontiers in Pharmacology · 2023 · 1 citations
    25. Blue honeysuckle (Lonicera caerulea L.) fruit extract promotes hair growth via β-catenin signaling pathway Food Science and Biotechnology · 2026
    26. Hair-Growth-Promoting Effects of the Fish Collagen Peptide in Human Dermal Papilla Cells and C57BL/6 Mice Modulating Wnt/β-Catenin and BMP Signaling Pathways International Journal of Molecular Sciences · 2022
    27. Human umbilical cord blood mesenchymal stem cells engineered to overexpress growth factors accelerate outcomes in hair growth The Korean Journal of Physiology and Pharmacology · 2018 · 21 citations
    28. A novel cell-penetrating peptide supports hair follicle growth through anti-inflammatory and growth factor–associated mechanisms in preclinical models BMC Biotechnology · 2026
    29. Recombinant Type XVII Collagen Promotes Hair Growth by Activating the Wnt/β-Catenin and SHH/GLI Signaling Pathways Cosmetics · 2025
    30. Platelet-Rich Plasma Contains High Concentrations of DKK1, A Potent Inhibitor of Wnt Signaling that Limits Bone Regeneration and Hair Growth Journal of orthopedics & bone disorders · 2023