72 citations
,
January 1983 in “The Anatomical Record” This study found that epidermal growth factor treatment in male mice delayed normal skin development, inhibiting hair growth and follicle development by maintaining birth-level cell proliferation and differentiation for several days.
29 citations
,
April 1997 in “Developmental Dynamics” This study found that topical trypsin application after hair removal in mice led to cell death at the follicular papilla, which delayed hair growth and pigmentation.
3 citations
,
April 1997 in “Developmental Dynamics” In this study, topical trypsin treatment following depilation in a mouse model induced cell death at the follicular papilla, delaying hair growth and pigmentation.
161 citations
,
August 2013 in “Journal of experimental botany” This study found that specific ATP-competitive TOR inhibitors (asTORis) decrease root growth in Arabidopsis thaliana in a dose-dependent manner, similar to their effects on mammalian cells.
51 citations
,
December 2003 in “The FASEB Journal” This study reports that AS101 induced hair growth in mice and suggests potential for treating chemotherapy-induced alopecia in humans, which was observed in case report studies with three adolescents.
3 citations
,
August 2003 in “PubMed” This study found that bergamot and boxthorn extract significantly improved skin antioxidant activity and collagen content while promoting hair growth in mice.
December 2024 in “Pediatrics in Review” This case report concluded that undiagnosed Menkes disease, an X-linked disorder causing copper deficiency, contributed to a 7-month-old's illness and death, complicating his presentation with viral septic shock and methamphetamine exposure.
10 citations
,
October 2017 in “Pediatric neurology” This case report suggests that poor hair and nail growth in children with autism spectrum disorder and developmental delay may indicate a biotin-responsive condition, as biotin and acetazolamide therapy improved symptoms and school performance in the reported patient.
2 citations
,
January 2010 In this study, the researchers found that an increased number of hairs less than 40 microns in diameter per cm² was associated with androgenic alopecia in both men and women.
December 2022 in “Biochemical and Biophysical Research Communications” This study found that HtrA2 inactivation in mnd2 mice is associated with delayed hair cycle phases and growth retardation of adipocytes, suggesting HtrA2's role in regulating adipogenesis-related hair growth.
63 citations
,
April 2005 in “Mechanisms of development” This study found that heterozygous mice overexpressing Claudin-6 experienced alterations in epidermal and hair follicle differentiation, leading to distinctive coat characteristics and a disrupted epidermal permeability barrier.
16 citations
,
January 1998 in “Dermatology” This study observed that vellus hairs and empty spaces are present in prepubertal children's scalps, but they likely do not indicate androgenetic alopecia, suggesting a natural 'true resting' phase of scalp hair.
6 citations
,
October 2015 in “Experimental dermatology” This study found that adenine supplementation in cultured human follicle dermal papilla cells stimulated proliferation and reduced senescence, possibly through AMPK activation and increased cellular NAD+ levels.
In this study, researchers observed that during zebrafish fin regeneration, osteoblast Erk activity, influenced by Fgf receptor signaling, forms gradients scaling with amputation length, which predicts regenerative tissue growth and skeletal structure size.
52 citations
,
February 2012 in “PloS one” This study found that the absence of Ctip2 in epidermal keratinocytes led to impaired wound healing in mice, affecting cell migration, proliferation, and hair follicle stem cell maintenance.
February 2022 in “Obstetrics and gynaecology cases - reviews” This case report highlights the diagnostic and management challenges of polycystic ovary syndrome, especially in young women with metabolic complications like type 2 diabetes.
August 2025 in “Stem Cell Reviews and Reports” This study demonstrated that adipose derived stem cells nanovesicles enhanced hair growth and reduced sebum secretion in androgenetic alopecia, showing effects comparable to minoxidil in laboratory and mouse models.
19 citations
,
March 2004 in “The Journal of Clinical Endocrinology & Metabolism” This study suggests that combining testosterone and letrozole may accelerate puberty in boys with constitutional delay by increasing serum androgen bioactivity and facilitating pubertal progression.
79 citations
,
August 1998 in “The Journal of Cell Biology” In a transgenic mouse model, this study found that overexpression of keratin 16 in skin keratinocytes led to hyperkeratosis and increased EGF receptor signaling, altering skin cell behavior and structure.
33 citations
,
September 2017 in “Molecules” This study found that red ginseng oil and its major components improved hair regrowth in testosterone-treated mice by promoting an earlier anagen phase and altering related gene expressions.
December 2019 in “Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü dergisi” In this case series, two cats with hypothyroidism and hyperthyroidism achieved clinical remission and normal thyroid function following timely diagnosis and targeted treatment with levothyroxine and methimazole, respectively.
5 citations
,
February 2003 in “American Journal of Medical Genetics Part A” This case report describes a 6.5-year-old girl with a balanced chromosome translocation involving chromosomes 1 and 6, linked to developmental speech delay and features suggestive of ectodermal dysplasia.
July 2022 in “International Journal of Contemporary Pediatrics” This report describes siblings with vitamin D-dependent rickets type 2, characterized by growth retardation, alopecia totalis, and low 25(OH)D3 levels, highlighting its autosomal recessive pattern and distinction from other rickets types.
August 2019 in “International journal of contemporary pediatrics” This case study reports that a 3 ½ year-old male with vitamin D-dependent type II rickets showed partial improvement in alopecia and rickets when treated with high doses of 1,25(OH)2 vitamin D3.
This article reviews the role of hormones in human penis development and associated conditions due to hormonal imbalances, but reports no new findings, suggesting hormone replacement can manage some conditions.
14 citations
,
December 2003 in “International Journal of Cosmetic Science” This review discusses the hair eclipse phenomenon in hair cycling and the potential roles of synchronizers and microinflammation in its occurrence, reporting no new empirical findings.
January 2023 in “Integrative Journal of Medical Sciences” This report presents a case of a child with hypothyroidism and poorly controlled type 1 diabetes developing both Mauriac syndrome and Van Wyk–Grumbach syndrome, two rare complications.
23 citations
,
December 2001 in “Lasers in Surgery and Medicine” This article discusses the extended theory of selective photothermolysis and does not report new clinical results; the authors explore potential applications in hair removal techniques.
12 citations
,
February 1986 in “PubMed” This study found that newborn mice given 6-aminonicotinamide developed skin, intestinal, and central nervous system lesions, offering insights into the mechanisms of pellagra.
2 citations
,
April 2011 in “InTech eBooks” This review discusses the potential skin care benefits of non-denatured soybean extracts, including skin lightening and UV protection, but reports no clinical results.