Adenine Supplement Delays Senescence in Cultured Human Follicle Dermal Papilla Cells

    October 2015 in “ Experimental dermatology ”
    Yingying Cheng, Guang‐Huar Young, Tsu‐Man Chiu, Jiun‐Tsai Lin, Ping Huang, Chao‐Yin Kuo, Yao‐Jen Liang, Po‐Ku Chen, Sung Fang Chen, Ching‐Yi Cheng, Han‐Min Chen
    Studysummary This study found that adenine supplementation in cultured human follicle dermal papilla cells stimulated proliferation and reduced senescence, possibly through AMPK activation and increased cellular NAD+ levels. Our plain-language summary of this paper — not a Tressless recommendation.
    The study demonstrated that adenine supplementation significantly stimulated the proliferation and inhibited the senescence of cultured human follicle dermal papilla cells (HFDPCs). Adenine activated AMP-activated protein kinase (AMPK) and increased cellular NAD+ levels, which are associated with anti-senescence effects. However, adenine-induced AMPK activation did not inhibit the mTOR signaling pathway. Microarray analysis confirmed that adenine prevented the decreases in gene expression related to proliferation and telomere maintenance. These findings suggested that adenine could be beneficial for expanding HFDPCs in vitro, potentially aiding therapeutic applications for hair growth.
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