Trypsin-Induced Follicular Papilla Apoptosis Results in Delayed Hair Growth and Pigmentation
April 1997
in “
Developmental Dynamics
”
Studysummary In this study, topical trypsin treatment following depilation in a mouse model induced cell death at the follicular papilla, delaying hair growth and pigmentation.
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The study demonstrated that topical application of trypsin, a serine protease, induced apoptosis in the follicular papilla of a synchronized hair growth mouse model, leading to delayed hair growth and pigmentation. This suggested that trypsin might influence a receptor-mediated signaling pathway responsible for cell death in the follicular papilla. The findings highlighted the role of proteases in programmed cell death and their potential impact on hair growth and pigmentation processes.
