Trypsin-Induced Follicular Papilla Apoptosis Results in Delayed Hair Growth and Pigmentation

The study demonstrated that topical application of trypsin, a serine protease, induced apoptosis in the follicular papilla of a synchronized hair growth mouse model, leading to delayed hair growth and pigmentation. This suggested that trypsin might influence a receptor-mediated signaling pathway responsible for cell death in the follicular papilla. The findings highlighted the role of proteases in programmed cell death and their potential impact on hair growth and pigmentation processes.