May 2017 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study describes a postmenopausal woman's diagnosis with ovarian hyperthecosis, confirmed by a GnRHa test normalizing testosterone, highlighting hormone therapy as a therapeutic option when surgery is not feasible.
October 2024 in “Journal of the Endocrine Society” This case report describes a patient with an ovarian steroid cell tumor that initially presented as non-classical adrenal hyperplasia, emphasizing the difficulty in differential diagnosis with hyperandrogenism and the importance of close clinical monitoring.
3 citations
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January 2017 in “Gynecological endocrinology” This case report describes a 63-year-old woman with hyperandrogenism due to an ectopic adrenal gland adenoma on the ovaries, successfully treated with bilateral salpingo-oophorectomy.
December 2020 in “Research Square (Research Square)” This case series detailed three postmenopausal women with ovarian steroid cell tumors, highlighting that such tumors may present asymptomatically or with virilization, and found surgery effectively normalized androgen levels, with distinctive imaging features aiding diagnosis.
July 2026 in “Journal of Ovarian Research” In this study, researchers used single-cell RNA sequencing to identify seven cell types, including distinct steroidogenic and immune cells, in the tumor microenvironment of a case of ovarian SCT-NOS, providing insights into its cellular heterogeneity and molecular mechanisms related to hyperandrogenism.
November 2022 in “Journal of the Endocrine Society” This case study reports a rare instance of a virilizing androgen-only secreting adrenal cortical adenoma in a 13-year-old, with symptom resolution after surgical removal.
October 2022 in “Miscellaneous” This study documented a case of a 57-year-old woman with postmenopausal virilism due to a Sertoli-Leydig cell tumor, which improved after surgical treatment.
5 citations
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November 2001 in “PubMed” This case report describes an 80-year-old woman with severe androgenic alopecia linked to Leydig cell hyperplasia in an ovarian cyst, highlighting the need to investigate androgen-secreting tumors in similar cases.
April 2020 in “Journal of the Endocrine Society” This case report describes a 58-year-old woman whose virilization symptoms were linked to a steroid tumor of the ovary, emphasizing the importance of prompt diagnosis and treatment to improve her quality of life.
November 2022 in “Journal of the Endocrine Society” This case report describes a rare instance of virilizing androgen production due to an ovarian serous cystadenoma in a 59-year-old woman, with testosterone levels normalizing after its removal.
19 citations
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June 1997 in “The Journal of Clinical Endocrinology & Metabolism” This case study details a 57-year-old woman with symptoms of androgen excess, including rapid hair growth and temporal balding, alongside abnormal testosterone levels and a history of chronic renal failure.
5 citations
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October 2013 in “Endocrine” This case report describes three instances where occult ovarian Leydig cell tumors were suspected based on severe hyperandrogenism symptoms, despite negative imaging findings, highlighting that elevated testosterone levels are a crucial diagnostic marker.
October 2024 in “Journal of the Endocrine Society” This case report details a diagnostic challenge in a postmenopausal woman with severe hyperandrogenism where distinguishing between adrenal and ovarian causes was complicated by elevated 17-OH Progesterone and asymmetric ovarian enlargement; pending surgical pathology is expected to guide further management.
July 2024 in “Journal of the ASEAN Federation of Endocrine Societies” In this case study, a 69-year-old woman with signs of virilization and high testosterone levels was found to have an ovarian steroid cell tumor, highlighting the importance of systematically investigating such symptoms in postmenopausal women to determine the underlying etiology and prevent poor prognosis.
October 2023 in “Journal of the Endocrine Society” In this case report, a post-menopausal woman with symptoms such as hirsutism and elevated testosterone underwent surgery, which revealed hormonally active ovarian cellular fibromas, leading to symptom resolution and normalized hormone levels; the authors suggest further exploration of these tumors' hormonal effects.
17 citations
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January 2013 in “Case Reports in Medicine” This review discusses steroid cell tumors of the ovary, their hormone production, symptoms, and evaluation, emphasizing surgery as the key treatment approach; it reports no new clinical results.
1 citations
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November 2002 in “Endocrine practice” This case report describes a post-menopausal woman with severe hirsutism whose high testosterone levels decreased after gonadotropin suppression, indicating residual hormone-producing tissue responsive to gonadotropins.
April 2024 in “International journal of reproduction, contraception, obstetrics and gynecology” This case report discusses a 17-year-old in Haiti diagnosed with a rare ovarian Sertoli-Leydig tumor, emphasizing the importance of considering future fertility and psychosocial effects when managing such conditions.
August 2017 in “Journal of pediatric surgery case reports” This case report details a functioning adrenocortical oncocytoma in a 3-year-old girl with hirsutism and virilization, highlighting its rarity in childhood and including a literature review without new clinical data.
October 2025 in “Journal of Obstetric and Gynaecological Practices POGS”
2 citations
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October 2015 in “Obstetrics and gynaecology cases - reviews” This case report details a postmenopausal woman with increased libido, hirsutism, and spontaneous orgasms, noting elevated testosterone levels and enlarged ovaries.
5 citations
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November 2018 in “Journal of Obstetrics and Gynaecology” This case series highlights that diagnosing ovarian Leydig cell tumors can be challenging, and expert sonography is crucial for accurate identification, as imaging modalities like CT, MRI, and PET-CT may fail to detect them.
October 2024 in “Journal of the Endocrine Society” In this case study, a postmenopausal woman with symptoms of virilization was diagnosed with a rare ovarian Leydig cell tumor, and surgical removal led to a resolution of her hyperandrogenism and related symptoms, highlighting the importance of thorough differential diagnosis in postmenopausal hyperandrogenism.
7 citations
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October 2019 in “Case reports in endocrinology” This case report describes a woman with hyperandrogenism and menstrual disturbances, where an ovarian steroid cell tumor was identified and removed, leading to resolution of symptoms.
October 2008 in “DOAJ (DOAJ: Directory of Open Access Journals)” This case report describes a 20-month-old female with a rare adrenocortical virilizing tumor, successfully treated with surgery, showing no pathological lesions over a 10-year follow-up.
October 2023 in “Clinical case reports” This case study reports the first Palestinian case of an ovarian steroid cell tumor with virilization in a young female, highlighting the challenges in diagnosis and varied chemotherapeutic responses.
3 citations
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June 2016 in “Gynecological Endocrinology” Doctors used a special blood sampling technique to diagnose a woman's rare ovarian tumor that was producing male hormones.
21 citations
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April 1995 in “Mayo Clinic Proceedings” This case study describes a testosterone-secreting adrenal adenoma in a 55-year-old woman, highlighting the presence of Reinke's crystalloids, suggesting that Leydig cells may play a role in such tumors.
October 2024 in “Journal of the Endocrine Society” This case report highlights the challenge of differentiating between non-classical adrenal hyperplasia and steroid cell tumors of the ovary in a patient presenting with hyperandrogenism.
1 citations
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August 2022 in “Case Reports” This case report describes a woman in her 30s who had virilisation and androgenic alopecia due to a testosterone-secreting ovarian tumor, which normalized after its surgical removal.