A Diagnostically Challenging Case of Hyperandrogenism in a Postmenopausal Woman
October 2024
in “
Journal of the Endocrine Society
”
Studysummary This case report details a diagnostic challenge in a postmenopausal woman with severe hyperandrogenism where distinguishing between adrenal and ovarian causes was complicated by elevated 17-OH Progesterone and asymmetric ovarian enlargement; pending surgical pathology is expected to guide further management.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
This case study discusses a 70-year-old postmenopausal woman with severe hyperandrogenism, characterized by elevated testosterone levels, excessive hair growth, male pattern hair loss, and weight loss. The diagnostic challenge lies in differentiating between ovarian hyperthecosis, non-classical congenital adrenal hyperplasia (NCCAH), and Sertoli-Leydig Cell Tumor (SLCT) due to elevated 17-OH Progesterone levels and asymmetrical ovarian enlargement. The patient underwent an ACTH stimulation test and imaging, revealing a prominent left ovary. She was referred for bilateral oophorectomy to obtain a definitive diagnosis. This case underscores the complexity of diagnosing hyperandrogenism in postmenopausal women and the importance of thorough differential diagnosis and laboratory analysis.
