Ovarian Steroid Cell Tumor Presenting As Non-Classical Adrenal Hyperplasia

    October 2024 in “ Journal of the Endocrine Society ”
    V. C. Reddy, A.P. Mallikarjuna Gowda, Vihaan Vattipally, Deepthi Kunduru
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    TLDR Ovarian steroid cell tumors can mimic adrenal hyperplasia, and surgery can normalize hormone levels.
    This case report discusses a 29-year-old Caucasian female with a rare ovarian steroid cell tumor (SCT) that initially presented as non-classical adrenal hyperplasia (NCAH). SCTs are uncommon, comprising less than 0.1% of ovarian tumors, and often secrete androgens, leading to symptoms similar to congenital adrenal hyperplasia (CAH) or polycystic ovary syndrome (PCOS). The patient experienced secondary amenorrhea, hirsutism, and male pattern hair loss, with initial treatment showing improvement. However, a sudden increase in androgen levels led to the discovery of a 10.4 cm ovarian mass, which was surgically removed. Post-surgery, hormone levels normalized, and steroid therapy was discontinued. The report emphasizes the importance of considering SCT in patients with hyperandrogenism and the need for careful monitoring to prevent irreversible symptoms.
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