TLDR Some ovarian tumors can cause masculinization, and it's important to check for various causes when this symptom is present.
The study, conducted over a 5-year period at a tertiary care gynaecological centre in Chennai, found that out of 592 ovarian malignancies, 36 cases (6.08%) were sex cord stromal tumours, with 4 cases (11%) presenting with virilisation. The most affected age group was 41 to 50 years, with a median age of 45, and the right ovary was more commonly involved. The study emphasized the importance of a comprehensive evaluation for patients with virilisation symptoms to exclude various causes, including ovarian neoplasms. It also highlighted the need for laboratory investigations to assess hyperandrogenism and differentiate between potential causes such as PCOS, CAH, adrenal tumors, and the effects of exogenous androgens. The document did not specify the number of patients studied for the incidence rates of virilization in sex cord-stromal tumors.
22 citations,
February 2014 in “Arquivos Brasileiros De Endocrinologia E Metabologia” An 81-year-old woman's severe male hormone symptoms were caused by an ovarian tumor, which was treated with surgery.
19 citations,
July 2013 in “The obstetrician & gynaecologist” The document concludes that careful evaluation is needed to diagnose PCOS correctly due to similar symptoms in other conditions, and accurate testosterone level measurement is crucial.
10 citations,
May 2009 in “Cases Journal” A woman's masculine symptoms were caused by an ovarian tumor, which improved after surgery.
19 citations,
September 2004 in “Reviews in gynaecological practice” Effective hirsutism management requires identifying the cause, combining new and traditional treatments, and setting realistic expectations for patients.
6 citations,
December 2010 in “Case Reports” A woman with high testosterone and an adrenal nodule had an ovarian tumor causing her symptoms, which improved after the tumor was removed.
20 citations,
October 2017 in “Clinical Endocrinology” The conclusion is that removing both ovaries is the best treatment for excess male hormones in postmenopausal women, with medication as another option, and managing insulin resistance is important for diagnosis and treatment.
7 citations,
October 2019 in “Case reports in endocrinology” A young woman's symptoms suggested PCOS, but tests and surgery confirmed and treated a rare ovarian tumor, resolving her condition.
November 2013 in “John Wiley & Sons, Ltd eBooks” The document concludes that accurate diagnosis of male and female gonadal disorders is crucial for effective treatment and better patient outcomes.
