Ovarian Steroid Cell Tumor Presenting as Non-Classical Adrenal Hyperplasia

October 2024 in “ Journal of the Endocrine Society ”

Venkata Ravi Prakash Reddy, A.P. Mallikarjuna Gowda, Vihaan Vattipally, Deepthi Kunduru

ovarian steroid cell tumor non-classical adrenal hyperplasia androgen excess hirsutism amenorrhea androgen levels ovarian mass hyperandrogenism polycystic ovary syndrome SCT NCAH PCOS

TLDR Early detection of ovarian steroid cell tumors is crucial to prevent lasting symptoms.

This document presents a case of a 29-year-old Caucasian female with a rare ovarian steroid cell tumor (SCT), initially misdiagnosed as non-classical adrenal hyperplasia (NCAH) due to similar symptoms of androgen excess, such as hirsutism and amenorrhea. Despite initial improvement with steroid therapy, a significant rise in androgen levels led to the discovery of a 10.4 cm ovarian mass, confirmed as SCT after surgical removal. The case highlights the diagnostic challenge of distinguishing SCT from NCAH or PCOS, emphasizing the need for careful monitoring and consideration of SCT in patients with hyperandrogenism, even when initial treatments appear effective. Early detection is crucial to prevent irreversible hyperandrogenic symptoms.

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