A Pure Androgen-Secreting Adrenal Cortical Tumor in a 13-Year-Old Female

    November 2022 in “ Journal of the Endocrine Society ”
    Rajan Senguttuvan, Gilda Brown, Kendall Cannon, Valeria Munguia Jovel
    Image of study
    TLDR A 13-year-old girl's masculine symptoms improved after surgery for a rare adrenal tumor that produced male hormones.
    A 13-year-old female presented with virilization symptoms, including a deep masculine voice, hirsutism, and elevated androgen levels, due to a rare androgen-secreting adrenal cortical adenoma. Initial lab results showed significantly elevated levels of 17-Hydroxypregnenolone, Androstenedione, Testosterone, DHEA, and DHEA-S, with normal LH, FSH, Estradiol, Cortisol, and Chromogranin A. Imaging revealed a large left adrenal mass, which was surgically removed. The pathology confirmed a Stage II adrenal cortical adenoma with a slightly increased ki67 index. Post-operatively, the patient's symptoms improved, including the resumption of regular menstrual periods, and normalization of DHEA-S levels. This case is notable as one of the first documented instances of a pure androgen-secreting adrenal cortical tumor in a pediatric patient without Cushing's syndrome symptoms.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

    Similar Research

    5 / 1000+ results
      Hirsutism and Virilization in the Female

      research Hirsutism and Virilization in the Female

      2 citations, January 2013 in “Elsevier eBooks”
      The chapter explains the causes of excessive hair growth and masculinization in women and how to measure hormone levels related to these conditions.
      The Case of the Elusive Androgen

      research The Case of the Elusive Androgen

      1 citations, November 2002 in “Endocrine practice”
      The patient's high testosterone was reduced by a medication that suppresses gonadotropin.
      Hirsutism

      research Hirsutism

      12 citations, November 1993 in “International Journal of Dermatology”
      The document explains that hirsutism, often caused by hormonal issues, can be managed with treatment to improve both physical appearance and mental health.