Aldosterone- and Cortisol-Cosecreting Adrenal Adenoma, Ovarian Hyperthecosis, and Breast Cancer

The document discusses three cases of women with hormonal dysfunctions and cancer. The first case is a 60-year-old woman with hypertension, hirsutism, and virilization, who was diagnosed with an aldosterone- and cortisol-cosecreting adrenal adenoma, ovarian hyperthecosis, and breast cancer. The second case is a 56-year-old woman with hypertension, hypokalemia, and severe alopecia, who had an adrenal mass causing primary aldosteronism and subclinical hypercortisolemia. Her alopecia did not improve after adrenalectomy, and she developed hyperandrogenic symptoms and estrogen receptor-positive breast cancer. The third case is a patient with a lipid-poor Aldosterone- and cortisol-cosecreting adrenal adenoma, ovarian hyperthecosis causing virilization, and ER-positive breast cancer. Her alopecia did not improve after the resolution of hypercortisolemia, and she required adrenal replacement therapy for 2.5 years. The document concludes that these cases highlight the importance of thorough investigation of hypertension and hormonal dysfunctions, and the potential link between these conditions and cancer.