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This review examines the role of Epigallocatechin Gallate in aging epigenetics but reports no new research findings.

This study found that aged C57BL/6 mice sub-strains exhibit distinct aging patterns, including differences in survival rates, body weight changes, and disease incidences, providing valuable insights for geriatric research using these mice models.

This study observed that MIRV improved gastrointestinal symptoms and other quality of life measures in patients with platinum-resistant ovarian cancer compared to chemotherapy.

This review discusses the role of microRNA in skin development and disease, highlighting its potential for novel therapies, and reports no clinical results.

This article discusses the potential benefits of GcMAF and oral MAF, developed by "Saisei Mirai", for cancer and other conditions, but reports no new clinical results.

Developing microRNA-based treatments is hard but has potential.

This study suggests that PDRN may enhance wound healing by reducing MIR135b expression, which in turn increases FOXO1 expression in keratinocytes.

This paper reviews the role of miRNAs in stem cell therapies and hair follicle growth, reporting no new findings but highlighting recent insights into fertility treatment and wound healing.

This study found that the proteins Par3, mInsc, and Gαi3 cooperate to regulate LGN polarization and promote perpendicular cell divisions during murine epidermal morphogenesis.

This review discusses the role of microRNAs in skin function and potential therapeutic applications, emphasizing their importance in wound healing and disease management, though it reports no new experimental findings.

This study found that induced expression of mir-302 can reprogram human hair follicle cells into induced pluripotent stem cells through a novel epigenetic mechanism involving global demethylation.

In this study, the authors used AI-driven methods to identify and prioritize promising therapeutic targets that may address both aging and Glioblastoma Multiforme, proposing CNGA3, GLUD1, and SIRT1 as novel candidates.

This review discusses regenerative medicine and explores the potential of molecular imaging in enhancing personalized therapies, but it reports no new research results.

Two studies in Cell Stem Cell reported that human and mouse somatic cells can be reprogrammed into induced pluripotent stem cells using microRNAs, eliminating the need for ectopic protein expression.

Micrografts are useful for healing wounds, regenerating bone and periodontal tissues, and improving hair transplantation outcomes.

This study found that topical application of recombinant human MG53 protein mitigated nitrogen mustard-induced skin injuries in mice by preserving epidermal integrity and hair follicle structure.

This study identifies a mechanism where dsRNA activates TLR3 to induce RA production, promoting hair follicle regeneration in mice and suggesting a potential role in human tissue regeneration.

This study identified a set of tumour-suppressive microRNAs (miRNAs), termed 'normomiRs', that are highly expressed in normal tissues but low in tumors, with miR-206 and miR-381 showing significant in vitro cancer inhibition, highlighting their potential for miRNA-replacement therapies across multiple cancer types.

This study found that deleting the miRNA processing enzymes Drosha and Dicer from mouse skin epithelial cells disrupted normal hair follicle development and maintenance, leading to follicular degradation and stem cell loss during the growth phase.

This study found that hair follicle stem cells are stiff with high actomyosin contractility, while hair germ progenitors are soft and enlarge during quiescence, influencing hair regeneration; inducing miR-205 reduces contractility and activates regeneration in mice.

This study found that in mice with premature ovarian insufficiency, miR-21 enhances ovarian function recovery following umbilical cord-derived mesenchymal stem cell transplantation by influencing specific cellular signaling and immune pathways.

This article provides a protocol for live imaging of C. elegans germline stem cells, highlighting their potential for studying mitosis and other cell processes, but does not report new experimental findings.

This review discusses skin tissue engineering and highlights the potential role of microRNAs in improving bioengineered skin equivalents, concluding that further exploration of microRNA targets could address unmet clinical needs.

In this study, bioengineered hair germ microspheres made from HME hydrogels promoted hair follicle regeneration in vivo, suggesting a promising approach for hair loss treatment.

This study discovered that exosomes from adipose-derived mesenchymal stem cells can mitigate damage in dermal papilla cells by modulating the TGF-β1/SMAD2 signaling pathway through miRNAs miR-574-3p and miR-125a-5p, revealing potential therapeutic targets for androgenetic alopecia.

This study observed that gerbils exhibit a different wound healing mechanism compared to mice, with lower TGF-B1 expression and distinct tissue responses, yet achieve similar healing outcomes.

This study demonstrated that a light-activated RNAi approach using hollow gold nanoshells effectively targets human prostate cancer cells with reduced off-target toxicity and material use compared to standard methods.

This article proposes using the hallmarks of ageing and dysregulated microRNAs to create a molecular morbidity score that could improve prognostication and clinical trial inclusion for patients with multimorbidity.

In this study, researchers found that hTERT/SV40 immortalization of human dermal fibroblasts up-regulates skin cell markers and highlights the SIRT1 and miR-93 pathways' roles in maintaining fibroblast proliferation, potentially benefiting developments in the cosmetic industry.

This review outlines recent advancements in understanding how micro-RNAs (miRNAs) influence hair regeneration, highlighting their role in stimulating hair growth and potential therapeutic approaches, while also addressing the challenges of clinical translation due to miRNAs' complex roles and delivery issues.