Study on Wound Healing Mechanism Through MicroRNA Regulation
January 2017
TLDR MIR135b affects wound healing by targeting genes, and PDRN may help heal wounds by altering this pathway.
The study explored the role of microRNA, specifically MIR135b, in the wound healing process. It was found that MIR135b targets the COL4A3 gene, and its inhibition increases the expression of type IV collagen, enhancing keratinocyte proliferation. The research identified FOXO1 as another target gene of MIR135b, confirmed through a luciferase reporter assay and western blot analysis. Additionally, treatment with polydeoxyribonucleotide (PDRN) reduced MIR135b levels and increased FOXO1 mRNA expression, suggesting that PDRN could promote normal skin wound healing by modulating the MIR135b-FOXO1 pathway. This study highlighted a potential new regulatory pathway in wound healing involving MIR135b and FOXO1.
