research Construction and Activity Analysis of K14/K5 Promoter Vector Containing Luciferase Gene
The K14 promoter is more active in skin cells than the K5 promoter.
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research MiR-218-5p Regulates Skin and Hair Follicle Development Through Wnt/β-Catenin Signaling Pathway by Targeting SFRP2
miR-218-5p helps skin and hair growth by targeting SFRP2 and activating a specific signaling pathway.
research Polyamine Oxidase Expression Is Downregulated by 17β-Estradiol via Estrogen Receptor 2 in Human MCF-7 Breast Cancer Cells
The study investigated the effect of 17β-estradiol on polyamine oxidase (PAOX) expression in estrogen receptor-positive MCF-7 breast cancer cells. It was found that 17β-estradiol significantly reduced both PAOX mRNA and protein levels. The repression of PAOX was mediated by estrogen receptor 2 (ESR2), as shown by experiments using selective ESR antagonists and knockdown of ESR members. A luciferase reporter assay indicated that 17β-estradiol downregulated PAOX promoter activity, and this effect was lost when specific activator protein 1 (AP-1) binding sites in the PAOX promoter were deleted or mutated. Chromatin immunoprecipitation analysis confirmed that ESR2 interacts with AP-1 at these sites. The findings suggested that 17β-estradiol represses PAOX transcription through ESR2's interaction with AP-1, implying that estrogen deficiency could lead to increased PAOX expression and decreased polyamine levels.
research Stat3 Partly Inhibits Cell Proliferation Via Direct Negative Regulation of FST Gene Expression
The protein STAT3 slows down cell growth by blocking the FST gene, which affects hair development in sheep.
research Transcriptional Characteristics Show That miR-144-y/FOXO3 Participates in Embryonic Skin and Feather Follicle Development in Zhedong White Goose
miR-144-y and FOXO3 play key roles in skin and feather development in Zhedong White geese.
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