Polyamine Oxidase Expression Is Downregulated by 17β-Estradiol via Estrogen Receptor 2 in Human MCF-7 Breast Cancer Cells
July 2022
in “
International Journal of Molecular Sciences
”
17β-estradiol estrogen receptor 2 polyamine oxidase PAOX MCF-7 breast cancer cells estrogen receptor-positive mRNA protein levels ESR2 selective ESR antagonists knockdown luciferase reporter assay promoter activity activator protein 1 AP-1 chromatin immunoprecipitation transcription estrogen deficiency estrogen ER2 breast cancer cells protein estrogen receptor antagonists gene knockdown reporter assay gene promoter gene transcription hormone deficiency
Studysummary This study found that in estrogen receptor-positive breast cancer cells, 17β-estradiol repressed polyamine oxidase transcription by interacting with AP-1 sites on its promoter.
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