Paxillin Regulates Androgen Receptor Expression Associated With Granulosa Cell Focal Adhesions

    April 2024 in “ Molecular Human Reproduction ”
    Adelaide Weidner, Anna Roy, Kenji Vann … Olga Astapova
    Studysummary This study found that paxillin knockdown in human granulosa-derived cells and mouse models decreased androgen receptor protein levels and altered gene expression, suggesting paxillin's role in protecting against androgen excess effects, as observed in a polycystic ovary syndrome mouse model.
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    Research cited in this study 1

    1. Comprehensive Overview of Polycystic Ovary Syndrome Nature Reviews Disease Primers · 2016