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Glossary Androgen Action

biological effects triggered by male sex hormones like testosterone

Androgen action refers to the biological effects triggered by androgens, which are male sex hormones like testosterone. These hormones bind to specific receptors in cells, influencing the development and maintenance of male characteristics, such as facial hair and muscle mass, and also play roles in female health. In the context of hair, androgen action can lead to hair growth in certain areas and contribute to conditions like androgenetic alopecia (pattern baldness).

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Research

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research Androgen actions on the human hair follicle: perspectives

115 citations , September 2012 in “Experimental Dermatology”

This article reviews the molecular mechanisms involved in androgenetic alopecia and the androgen's paradoxical role in hair growth, but reports no new experimental findings.

research Androgen Action in the Ovary

62 citations , August 2018 in “Frontiers in Endocrinology”

This review discusses the physiological roles of ovarian androgens in follicle development and atresia, emphasizing their contributions to polycystic ovary syndrome and normal follicle maturation but provides no new clinical results.

research Androgen action on human skin – from basic research to clinical significance

147 citations , October 2004 in “Experimental dermatology”

This paper reviews the role of androgens in human skin function and the challenges in developing treatments for androgen-associated disorders, reporting no new experimental results.

Antiandrogen Drugs Lower Serum Prostate-Specific Antigen Levels in Hirsute Subjects: Evidence That Serum PSA Is a Marker of Androgen Action in Women

research Antiandrogen Drugs Lower Serum Prostate-Specific Antigen (PSA) Levels in Hirsute Subjects: Evidence That Serum PSA Is a Marker of Androgen Action in Women¹

16 citations , January 2000 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

This study found that serum PSA levels are higher in hirsute women and can be significantly reduced by antiandrogen treatment, suggesting PSA as a marker of androgen action in females.

research Is the metabolism of testosterone to 5α-dihydrotestosterone required for androgen action in the skin?

14 citations , November 1982 in “British Journal of Dermatology”

This article discusses whether testosterone's metabolism to 5α-dihydrotestosterone is necessary for androgenic effects in the skin but reports no new experimental results.

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Community Join

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community A Technical Question About Pyrilutamide

in Research/Science 5 upvotes 3 years ago

Pyrilutamide is believed to be more effective than RU58841 and 1 mg finasteride in treating hair loss, with no systemic hormonal effects and the potential to block more than 31% of scalp DHT. It may also antagonize scalp testosterone due to its action as an androgen receptor antagonist.

community Finasteride's impact on blood pressure - mechanism of action

4 upvotes 5 years ago

Finasteride may cause mild blood pressure-related side effects in less than 10% of users, unlike minoxidil, which has stronger effects. Alternatives like topical ketoconazole and dermarollers are suggested for those concerned about finasteride's side effects.

community Research: Minoxidil grows hair by suppressing androgen activity (DHT) in hair follicles.

43 upvotes 6 years ago

Minoxidil may suppress androgen activity in hair follicles, potentially aiding in hair growth and prostate cancer treatment. Users discuss the effectiveness of minoxidil and finasteride for hair maintenance and regrowth, with some preferring topical applications over oral due to safety concerns.

community Having androgen receptor density and sensitivity at wrong f*ing place

in Satire 7 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

community Bicalutamide effect on androgens?

5 upvotes 5 years ago

Bicalutamide blocks androgen receptors, preventing testosterone and DHT from binding, which can help with hair loss but may cause feminization. It is not recommended for those who do not want feminization effects.

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