The Effects of Estradiol, Androgens, and Selective Estrogen Modulators: Ospemifene, Raloxifene, and Tamoxifen on Explant Cultures of Human Breast Tissue

    May 2013 in “ UTUPub (University of Turku) ”
    Natalija Eigėlienė
    TLDR Including androgens in hormone therapy may lower breast cancer risk.
    This study investigated the effects of various hormones and selective estrogen receptor modulators (SERMs) on human breast tissue to understand the potential risks of menopausal hormone therapy (MHT) related to breast cancer. Using a modified tissue explant culture system, the research found that estradiol (E2) and medroxyprogesterone acetate (MPA) increased cell proliferation, while androgens like testosterone (T) and dihydrotestosterone (DHT) inhibited proliferation and increased apoptosis, counteracting E2's effects. Postmenopausal breast tissues were more sensitive to E2 than premenopausal tissues. SERMs such as ospemifene, raloxifene, and tamoxifen showed antiproliferative effects similar to breast cancer treatments. The study concluded that including androgens in MHT could potentially reduce breast cancer risk by opposing E2-induced proliferation.
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