Antiaging Effect of Tea Epigallocatechin Gallate and Its Role in Modifying Aging Epigenetics: A Systematic Review

January 2023 in “ Pharmacophore ”

Reema A. Alyamani, Nada A. Almatrafi

Epigallocatechin Gallate EGCG epigenetics miRNA histone acetylation AcH3K9 HDAC1 gero-miRNAs tea extract

TLDR Tea compound EGCG may slow aging by affecting gene activity.

This systematic review explores the antiaging effects of Epigallocatechin Gallate (EGCG), a compound found in tea, and its role in modifying aging-related epigenetic marks. The review focuses on studies conducted between 2011 and 2020, examining the impact of EGCG on aging in mice models. EGCG is shown to influence muscle aging by modifying miRNA, which reduces gene expression and proteins linked to muscle wasting. Additionally, EGCG enhances cardiac diastolic function by increasing AcH3K9 and reducing HDAC1 expression. The findings suggest that EGCG is a significant epigenetic-modifying phytochemical that can restore histone acetylation and regulate aging-associated gene activity through gero-miRNAs.

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Antiaging Effect of Tea Epigallocatechin Gallate and Its Role in Modifying Aging Epigenetics: A Systematic Review

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research Cellular Senescence: Ageing and Androgenetic Alopecia

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