Antiaging Effect of Tea Epigallocatechin Gallate and Its Role in Modifying Aging Epigenetics: A Systematic Review

January 2023 in “ Pharmacophore ”

Reema A. Alyamani, Nada A. Almatrafi

Epigallocatechin Gallate EGCG epigenetics miRNA histone acetylation AcH3K9 HDAC1 gero-miRNAs tea extract

Studysummary This review examines the role of Epigallocatechin Gallate in aging epigenetics but reports no new research findings. Our plain-language summary of this paper — not a Tressless recommendation.

This systematic review explores the antiaging effects of Epigallocatechin Gallate (EGCG), a compound found in tea, and its role in modifying aging-related epigenetic marks. The review focuses on studies conducted between 2011 and 2020, examining the impact of EGCG on aging in mice models. EGCG is shown to influence muscle aging by modifying miRNA, which reduces gene expression and proteins linked to muscle wasting. Additionally, EGCG enhances cardiac diastolic function by increasing AcH3K9 and reducing HDAC1 expression. The findings suggest that EGCG is a significant epigenetic-modifying phytochemical that can restore histone acetylation and regulate aging-associated gene activity through gero-miRNAs.

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research Cellular Senescence: Ageing and Androgenetic Alopecia

January 2023 in “Dermatology”

This review summarizes biological links between aging and androgenetic alopecia, particularly focusing on cellular senescence, and discusses potential therapeutic strategies, but reports no new clinical results.