The Mechanisms of MicroRNA 21 in Premature Ovarian Insufficiency Mice with Mesenchymal Stem Cells Transplantation

The study explores the role of microRNA 21 (miR-21) in the treatment of premature ovarian insufficiency (POI) in mice through the transplantation of umbilical cord-derived mesenchymal stem cells (UCMSCs). It demonstrates that miR-21 enhances ovarian function recovery by suppressing the PTEN/AKT/FOXO3a signaling pathway and increasing CD8+CD28-T cells and interleukin 10 (IL-10) levels. The study involved 54 mice and showed that UCMSCs with enhanced miR-21 expression led to improved ovarian morphology and hormone levels, suggesting miR-21's potential as a therapeutic target for POI.