23 citations
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September 2015 in “PLOS ONE” This study found that mesenchymal stem cells, especially when injected intradermally, significantly accelerated wound healing in rats compared to chitosan treatment.
3 citations
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January 2022 in “PLoS ONE” In this study using a rat full-thickness burn model, the amnion bilayer dressing showed better healing and skin recovery than the standard protocol, including quicker complete healing and restored skin appendages.
14 citations
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November 2020 in “International Journal of Biological Macromolecules” This study found that Flammulina velutipes polysaccharides-derived scaffolds greatly enhanced wound healing and hair follicle regeneration in a rat model, particularly with the FPS/NaOH variant showing the best results.
28 citations
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February 2014 in “PLoS ONE” This study reports that transplantation of an ESCs-collagen-chitin biomimetic membrane leads to successful in situ skin regeneration, including hair follicle cell proliferation and formation of dermatoglyphs, in nude mice with full-thickness skin defects.
4 citations
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June 2022 in “Clinical, cosmetic and investigational dermatology” In this study, researchers introduced the Sanusi FUE Score Scale to better predict and grade the difficulty of follicular unit excision hair transplantation by accounting for diverse hair and skin types, with further validation needed.
38 citations
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June 2016 in “Journal of Tissue Engineering and Regenerative Medicine” This study demonstrated that implanting μm-scale full-thickness columns of human skin tissue into immunodeficient mice restored key features of normal human skin, suggesting potential for human wound repair with minimal donor site morbidity.
In this study, the researchers developed a biomimetic multilayer composite scaffold combining a decellularized amniotic membrane, fibroblast-laden collagen gel, and epidermal stem cells, which healed full-thickness skin wounds more quickly and effectively by regenerating hair follicles without scarring compared to Moropicin ointment.
39 citations
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June 2018 in “Burns” This study found that the spiny mouse can regenerate tissues such as skeletal muscle, dermis, and hair without scarring after full thickness thermal burns, unlike the lab mouse.
March 2017 in “Dermatologic Surgery” This journal overview describes the Dermatologic Surgery journal's focus on cosmetic and reconstructive skin surgery but reports no new research findings.
40 citations
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January 2022 in “Frontiers in Chemistry” This study found that a microneedle array patch using a blend of kangfuxin, chitosan, and fucoidan significantly accelerated wound healing in rats by enhancing epithelial thickness and collagen deposition.
9 citations
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November 2017 in “Frontiers in Pharmacology” This study found that Shengfu oil may enhance wound healing in scalded rabbit skin by regulating proteins β-catenin, Dlk1, and COX-2, due to its anti-inflammatory, analgesic, and antimicrobial properties.
March 2026 in “Acta Histochemica” 11 citations
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January 2013 in “Journal of the Saudi Society of Dermatology & Dermatologic Surgery” This study found that applying silymarin gel topically on rat wounds improved fibroblast proliferation, collagen formation, and wound closure more than a gel-base alone or no treatment.
January 2026 in “Advanced Science” In this study, a chronotherapeutic bilayer dressing system showed enhanced diabetic wound healing in a model by reducing inflammation through polyphenols and promoting repair with sustained PDGF-BB delivery, leading to faster re-epithelialization and hair follicle regeneration.
29 citations
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September 2019 in “Stem Cells International” This study observed that a treatment combining platelet-rich fibrin and micrograft spray-on skin led to rapid and complete wound healing in both massive and chronic burn patients within an average of 7-10 days.
26 citations
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April 2011 in “Skin Research and Technology” This study found that in vivo confocal scanning laser microscopy accurately quantifies neogenic hair follicles in mice, producing results similar to histology while avoiding fixation artifacts.
10 citations
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September 2018 in “Regenerative Medicine” This review explores the mechanism and potential applications of wound-induced hair follicle neogenesis but reports no new clinical results, highlighting the need for further research in hair regeneration therapies.
7 citations
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November 2021 in “Clinical, Cosmetic and Investigational Dermatology” This study describes a novel FUE device that may perform successfully across various patient scenarios, adapting to differences in skin firmness, thickness, and hair curliness.
August 2004 in “Journal of the American College of Surgeons” Dermagraft and Dermalogen had a lot of granulation, while Alloderm, Integra, and ADM had good blood vessel growth for skin healing.
15 citations
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January 2019 in “Experimental Dermatology” In this study, full-thickness wounding on Lanyu pigs led to scar formation and disrupted cell markers, while partial-thickness wounding allowed limited regeneration of rete ridges and papillary dermis.
3 citations
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August 2011 in “InTech eBooks” This article discusses the applications and contraindications of skin grafts in wound treatment and reports no new research findings.
June 2017 in “International Journal of Periodontics & Restorative Dentistry” This study found that using retroauricular full-thickness skin grafts in vestibuloplasty contributed to successful cosmetic and functional outcomes in dental implant rehabilitation for patients with mandibular gunshot injuries.
This study found that Fraser's Dolphin, a tight-skinned mammal, can regenerate complex skin architecture with minimal scarring after large full-thickness wounds, even in high-tension environments, offering insights into regenerative healing mechanisms typically obscured by fibrotic responses.
18 citations
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September 2006 in “Dermatologic Surgery” This study reported that squamous cell carcinomas of the scalp can become extraordinarily aggressive, highlighting the need for early diagnosis and careful use of treatment strategies like wide excision and radiation therapy.
September 2006 in “Dermatologic Surgery” This study reported that squamous cell carcinomas of the scalp can be extraordinarily aggressive, potentially metastasizing and causing death, highlighting the need for early diagnosis and careful treatment approaches.
September 2002 in “Dermatologic Surgery” This article offers guidance for hair transplant surgeons on addressing old or poorly executed transplants, focusing on surgical precision and effective use of limited donor hair to enhance cosmetic outcomes.
2 citations
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February 2021 in “European Journal of Plastic Surgery” This study found that the Fibonacci 'snail' flap for scalp defect reconstruction healed faster and resulted in better aesthetic outcomes than skin grafts, though not all complication rate differences were statistically significant.
48 citations
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December 2022 in “Biomolecules” This review discusses recent advancements in 3D bioprinting for skin regeneration and describes potential improvements for clinical applications, but it reports no new experimental results.
July 2026 in “Preprints.org” In this case study, a comprehensive reconstruction approach using autologous fat grafting, follicular unit excision hair transplantation, and scalp micropigmentation led to significant aesthetic and psychosocial improvements in a male patient with severe facial and scalp burn injuries.
6 citations
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January 2023 in “npj regenerative medicine” This study found that transplanting hair follicles into human scars may remodel fibrotic tissue and reduce scarring by altering collagen structure and decreasing pro-fibrotic factors.