Neovascularization During Healing of Wounds Treated with Dermal Substitutes and Fibrin Glue in Nude Mice

In the study titled "Neovascularization during healing of wounds treated with dermal substitutes and fibrin glue in nude mice," researchers investigated the neovascularization, or the formation of new blood vessels, in full-thickness skin wounds on nude mice that had been implanted with various dermal substitutes. The substitutes included Integra, Alloderm, acellular dermal matrix (ADM), Dermalogen, Dermagraft, and combinations with fibrin glue (FG) and human keratinocytes (KC). The mice were biopsied weekly for 4 weeks, and immunostaining for laminin and endoglin was used to evaluate blood vessel ingrowth. The results showed that Dermagraft and Dermalogen experienced extensive granulation, Alloderm had limited vascularity which normalized by day 28, and ADM and Integra showed rapid but controlled vessel ingrowth. The study concluded that while Dermagraft and Dermalogen underwent extensive granulation, Alloderm, Integra, and ADM showed progressive vessel ingrowth conducive to dermal regeneration and reepithelialization.