8 citations
,
August 2023 in “Lasers in Surgery and Medicine” This study observed that treating acne scars with fractional ablative laser concurrently with isotretinoin improved outcomes more effectively compared to applying the laser 6 months after isotretinoin treatment ended, as measured by the Quantitative Global Acne Scarring Grading System.
3 citations
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March 2019 in “Chinese Medical Journal” In this study using mice, fractional CO2 laser therapy promoted hair regrowth by inducing moderate inflammation, enhancing VEGF-mediated angiogenesis, and activating the Wnt10b signaling pathway.
January 2026 in “Dermatologic Therapy” This study found that combining ablative fractional CO2 laser treatment with topical minoxidil significantly improved frontal hairline regrowth and patient satisfaction in men with androgenetic alopecia compared to using minoxidil alone, without serious adverse effects.
January 2025 in “Dermatologic Therapy” This study found that ablative fractional carbon dioxide laser treatment improved skin fibrosis, reduced skin hardening, and enhanced hair follicle growth in localized scleroderma patients, with significant improvements across several clinical measures and no severe adverse effects observed.
October 2025 in “Iraqi postgraduate medical journal” This study observed that using fractional CO2 laser-assisted delivery of clobetasol propionate cream significantly improved treatment outcomes for localized alopecia areata compared to the cream alone, suggesting the laser's enhancing effect on hair regrowth.
2 citations
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January 2023 in “Biomedicines” This study found that using a combination of ablative CO₂ fractional laser and fetal fibroblast transplantation significantly reduced scarring in mice, with long-term sphere-forming cultured fibroblasts producing scar appearances closest to normal skin.
26 citations
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May 2015 in “Lasers in Surgery and Medicine” This study concluded that ablative fractional lasers may induce hair regrowth in mice by activating the Wnt/β-catenin pathway.
June 2023 in “QJM: An International Journal of Medicine” This study found that combining fractional CO2 laser treatment with platelet-rich plasma led to a statistically significant improvement in hair regrowth for male androgenetic alopecia, compared to using the laser treatment alone.
22 citations
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September 2022 in “Medicina” This study found that the dual-wavelength non-ablative fractional laser provides enhanced skin rejuvenation by increasing thermal lesion coverage and collagen remodeling compared to using the CO2 laser alone in an ex vivo setting.
3 citations
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August 2024 in “Journal of Cosmetic Dermatology” This study found that using ablative fractional CO₂ laser therapy combined with FUE treatment in patients with post-traumatic eyebrow scars and defects improved follicular survival rates and resulted in well-defined eyebrow shapes.
January 2023 in “The Egyptian Journal of Hospital Medicine ” This review suggests that fractional CO2 laser treatment may be a promising option for treating alopecia areata with a good safety profile.
25 citations
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August 2017 in “Lasers in Medical Science” This literature review reported that fractional lasers, like the 1550-nm nonablative erbium-glass laser, may enhance hair regrowth by stimulating a wound healing process, but more randomized controlled trials are needed to confirm their effectiveness and optimize treatment parameters.
January 2025 in “Journal of Biosciences and Medicines” This narrative review explores contraindications for fractional CO2 laser treatment of aesthetic disorders, highlighting conditions such as pigmentary disorders, active skin conditions, photosensitivity, and recent isotretinoin use, emphasizing the importance of careful patient selection to minimize risks and enhance safety and effectiveness.
27 citations
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August 2014 in “Journal of Cosmetic and Laser Therapy” This study compared the microscopic treatment zones created by different fractional lasers and radiofrequency in swine skin, finding distinct patterns and damage levels for each technology.
26 citations
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May 2017 in “Lasers in Medical Science” This study found that combining ablative fractional CO₂ laser therapy with hair growth factors significantly increased hair density in men with androgenetic alopecia compared to using growth factors alone.
This review concluded that laser-based therapies, particularly low-level lasers and fractional ablative lasers, are effective for treating hair loss, with combination therapies showing superior efficacy compared to monotherapies.
1 citations
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March 2024 in “International Journal of Dermatology” This case report describes a therapy-resistant folliculitis decalvans patient who showed nearly complete response with increased hair density after treatment with CO2 laser-assisted photodynamic therapy.
17 citations
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January 2021 in “Dermatology and Therapy” This review discusses laser-assisted drug delivery for enhancing topical treatment efficacy in various dermatological and medical applications but reports no new clinical results, emphasizing the need for further research to optimize its use.
2 citations
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January 2022 in “Skin appendage disorders” This study presents two cases where intralesional methotrexate combined with ablative fractional CO2 laser treatment resulted in excellent outcomes for refractory alopecia areata.
9 citations
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January 2023 in “Indian Dermatology Online Journal” This review discusses the use of aesthetic treatments for medical purposes and their therapeutic potential but provides no new clinical results.
January 2024 in “RSC pharmaceutics” This source discusses using stratum corneum ablation as a promising method to enhance transdermal drug delivery by temporarily removing the skin's outermost barrier to improve medication absorption.
40 citations
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September 2014 in “Journal of cosmetic and laser therapy” This case series found that combining ablative fractional resurfacing and acoustic pressure ultrasound with triamcinolone treatment led to complete recovery in patients with areata alopecia.
1 citations
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March 2019 in “Lasers in Surgery and Medicine” This article contains the late-breaking abstracts from the 39th Annual Conference of the American Society for Laser Medicine and Surgery and does not present new research results.
April 2024 in “Lasers in medical science” This study reviews the use of lasers and light therapies as treatment options for managing the two most common types of alopecia—androegenetic alopecia and alopecia areata—highlighting that existing FDA-approved drugs like minoxidil and finasteride are partially effective, necessitating additional therapeutic approaches.
18 citations
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May 2013 in “Journal of Dermatological Treatment” This study found that non-ablative fractional laser treatments in Korean patients had a low complication rate, with adverse events being temporary and not resulting in long-term consequences.
In this study involving 13 patients with vitiligo-associated leukotrichia, minimal hair repigmentation was observed following treatment with fractional CO₂ laser and topical betamethasone, though the method was well tolerated, highlighting the need for further research to optimize treatment parameters.
46 citations
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March 2013 in “Journal of Cosmetic and Laser Therapy” This study found that non-ablative and/or ablative fractional lasers promoted hair growth in patients with certain uncommon hair disorders, though effectiveness varied among different conditions.
2 citations
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April 2025 in “Lasers in Medical Science” This study found that combining fractional CO₂ laser with halometasone cream improved chronic eczema more effectively than halometasone alone, with efficacy varying by laser parameters and showing better results at 4 weeks compared to 1 week. Pain was noted with higher energy treatments.
24 citations
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November 2021 in “PLoS ONE” In this study, fractional laser treatment was observed to reverse age-related gene expression changes in skin and enhance dermal remodeling, further improved by multiple treatments.
24 citations
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January 2016 in “Lasers in Medical Science” This study found that non-ablative fractional erbium glass laser treatment affected gene regulation in human skin models by downregulating MMP and interleukin expression, suggesting potential roles in dermal remodeling and anti-inflammatory effects.