Fractional Ablative CO2 Laser and Oral Isotretinoin—A Prospective Randomized Controlled Split-Face Trial Comparing Concurrent Versus Delayed Laser Treatment for Acne Scars

    August 2023 in “ Lasers in Surgery and Medicine ”
    Eyal Taleb, Elisa S. Gallo, Fares Salameh, Amir Koren, Waseem Shehadeh, Ofir Artzi
    Studysummary This study observed that treating acne scars with fractional ablative laser concurrently with isotretinoin improved outcomes more effectively compared to applying the laser 6 months after isotretinoin treatment ended, as measured by the Quantitative Global Acne Scarring Grading System. Our plain-language summary of this paper — not a Tressless recommendation.
    This study investigated the effectiveness of fractional ablative CO2 laser (FACL) treatment for acne scars when administered concurrently with oral isotretinoin (ITN) versus delayed treatment 6 months after ITN cessation. In a prospective split-face randomized controlled trial, patients received FACL on one side of the face concurrently with ITN and on the other side 6 months post-ITN. The results showed that the concurrent treatment significantly improved acne scars, with a lower Global Acne Scarring Grading System (GASGS) score (4.7 ± 2.5) compared to the delayed treatment (7.7 ± 2.9), indicating that concurrent FACL-ITN treatment is more effective. The study was limited by standardized laser settings not tailored to individual skin types.
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