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research Effect of Primary Biotin Deficiency on the Skin of Germ-Free and Conventional Mice Fed a Purified Biotin-Deficient Diet without Supplementation with Egg White.
This study found that germ-free mice on a biotin-deficient diet exhibited significant weight loss and severe alopecia, unlike conventional mice on the same diet.
research 078 The transmembrane protein LRIG1 regulates receptor tyrosine kinases in skin development and homeostasis
LRIG1 protein affects hair growth by regulating skin receptors, leading to hair loss when overexpressed.
research Virtual memory is a big hairy deal
CD8+ virtual memory T cells may cause hair loss in alopecia areata.
research A rare hair loss in children: Monilethrix
Monilethrix is a rare, inherited condition causing fragile hair and hair loss, with no cure but some treatments may help.
research Controlled Delivery of T-box21 Small Interfering RNA Ameliorates Autoimmune Alopecia (Alopecia Areata) in a C3H/HeJ Mouse Model
This study found that local injections of interleukin-4 and neutralizing anti-interferon-γ antibody effectively treated alopecia in a mouse model, suggesting potential therapeutic pathways for human alopecia areata.
research An unusual pattern of alopecia areatas
A man had an unusual type of hair loss that didn't match known patterns and didn't improve with treatment.
research TELOGEN EFFLUVIUM: A LATE COMPLICATION OF INFLUENZA A Sw H1N1 PNEUMONIA
Hair loss can happen after severe H1N1 flu but usually grows back in 4 months.
research Intercellular Adhesion Molecule-1 and Hair Follicle Regression
This study found that ICAM-1 expression in murine skin is developmentally regulated and crucial for skin and hair follicle remodeling beyond its recognized role in immune responses.
research Alopecia in a Novel Mouse Model RCO3 Is Caused by mK6irs1 Deficiency
A missing mK6irs1 gene causes hair loss in mice.
research Complete defect in PA-PLA1α secretion function leading to autosomal recessive woolly hair and hypotrichosis: insights from a novel compound heterozygous LIPH variant study in a Chinese pedigree
This study reported discovering a novel missense variant in a case of autosomal recessive woolly hair in a 31-year-old Chinese woman, which significantly reduced secretion of the encoded protein, likely leading to disease by impairing its hydrolytic function.
research Genetic Ablation of the CDP/Cuxi> Protein C Terminus Results in Hair Cycle Defects and Reduced Male Fertility
This study found that mice with a mutant CDP/Cux protein lacking the homeodomain showed severely impaired growth, high postnatal mortality, and reduced fertility, highlighting CDP/Cux's role in developmental regulation.
research The metabolically protective energy expenditure increase ofPik3r1i>-related insulin resistance is not explained by Ucp1-mediated thermogenesis
This study found that Pik3r1 Y657* mice, which model human SHORT syndrome, show increased energy expenditure despite insulin resistance, but this is not due to changes in locomotion, thermoregulation, or Ucp1-dependent thermogenesis, suggesting a different metabolic mechanism may protect against lipotoxicity.
research Multisystemic eosinophilic epitheliotropic disease in a horse
In this case report, veterinarians observed a 16-year-old mare with symptoms including chronic weight loss, pruritus, muscle atrophy, and lameness, which gradually progressed to neurological issues despite initial treatment.
research The Gross Morphology and Scanning Electron Microscopic Evaluation of the Skin Surface in Congenic Strains of Hairless Mice
This study observed that hairless mice of different strains initially grow hair but soon develop alopecia and other skin and pigmentation changes with age.
research Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of Foxn1i> in Thymic Epithelial Cells
This study identified a regulatory element necessary for Foxn1 expression specifically in mouse thymic epithelial cells, crucial for thymus development but not affecting hair follicles.
research Skin regional specification and higher-order HoxCi> regulation
This study found that the unique crest feather formation in Polish chickens is driven by a 195-bp duplication in the HoxC10 gene region, which alters gene expression by modifying the genomic structure, suggesting a mechanism for diverse integumentary appendages in birds.
research ATRICHIA WITH PAPULAR LESIONS – A CASE REPORT
This report describes a rare case of papular atrichia in a 4-year-old girl, highlighting the absence of effective treatment to stimulate hair growth for this condition.
research Hair transplantation in mice: Challenges and solutions
In this study, researchers developed a new murine model for transplanting vibrissae that mimics human hair transplantation, achieving successful hair growth in immune-deficient nude mice.
research Itpr3 Is Responsible for the Mouse Tufted (tf) Locus
This study identified the Itpr3 gene as responsible for the tufted hair loss phenotype in the BTBR mouse strain.
research Comparative genomics analyses of alpha-keratins reveal insights into evolutionary adaptation of marine mammals
In this study, the researchers reported extensive gene loss and high pseudogenization rates of α-keratin genes in cetaceans compared to terrestrial mammals, likely linked to hair loss and aquatic adaptations.
research Uncombable-hair Syndrome
This report identified longitudinal grooves in the hair shafts of four children, diagnosing them with uncombable-hair syndrome.
research Global behavior of solutions in a chemotaxis model for alopecia areata with signal-dependent sensitivity
This study developed and analyzed a mathematical model for alopecia areata involving interactions among immune cells and cytokines, establishing conditions under which hairless patches can become stable and pervasive, particularly with certain biological rate levels and chemotactic sensitivities.
research Evidence for Novel Functions of the Keratin Tail Emerging from a Mutation Causing Ichthyosis Hystrix
This study reports the first keratin gene mutation affecting the tail domain, leading to a unique cytoskeletal abnormality and severe epidermal hyperkeratosis, highlighting the tail domain's critical role in keratin organization.
research ILK modulates epithelial polarity and matrix formation in hair follicles
This study found that ILK deficiency disrupts hair follicle development by impairing cell polarity and laminin-511 assembly, but these defects can be partially reversed with exogenous laminin-511.
research The IREi> gene encodes a protein kinase homologue and modulates root hair growth in Arabidopsisi>
This study identified a mutant in Arabidopsis with shorter root hairs due to early growth cessation, implicating the IRE gene in regulating root hair growth duration.
research Zinc deficiency in female rabbits
In this study, inducing zinc deficiency in recently weaned female Tan rabbits led to reduced food consumption, weight loss, and reproductive issues, including inactive uterine and ovarian changes.
research A Case of Loose Anagen Hair Syndrome in a Southeast Asian Boy
This case report describes the first known instance of loose anagen hair syndrome in a Southeast Asian child, a 13-year-old Thai boy with hair thinning and excessive shedding on the frontal scalp.
research Male pattern hair loss: Taking one for the team: The selfless gene
This article suggests that male pattern hair loss might have historically served as an evolutionary signal for women to choose younger male partners, potentially improving population fitness.
research Long-term live imaging of theDrosophilai>adult midgut reveals real-time dynamics of cell division, differentiation, and loss
This study describes a new imaging platform for the adult Drosophila midgut, facilitating real-time observation of cell behaviors and dynamics involved in organ renewal.