Skin Regional Specification And Higher-Order HoxC Regulation

    March 2025 in “ Science Advances ”
    Shu-Man Hsieh Li, Ya‐Chen Liang, Ting-Xin Jiang … Cheng‐Ming Chuong
    Studysummary This study found that the unique crest feather formation in Polish chickens is driven by a 195-bp duplication in the HoxC10 gene region, which alters gene expression by modifying the genomic structure, suggesting a mechanism for diverse integumentary appendages in birds.
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    Research cited in this study 5

    1. The Crest Phenotype in Domestic Chicken Is Caused by a 195 bp Duplication in the Intron of HOXC10 G3 Genes Genomes Genetics · 2021
    2. Morpho-Regulation in Diverse Chicken Feather Formation: Integrating Branching Modules and Sex Hormone-Dependent Morpho-Regulatory Modules Development, Growth & Differentiation · 2018
    3. Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration Cell Stem Cell · 2018
    4. Module-Based Complexity Formation: Periodic Patterning in Feathers and Hairs Wiley Interdisciplinary Reviews-Developmental Biology · 2012
    5. WNT Signaling in the Control of Hair Growth and Structure Developmental biology · 1999