50 citations
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September 2012 in “Developmental Biology” Sprouty and FGF balance is crucial for normal feather shape and size.
99 citations
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July 2012 in “PLoS Genetics” The study identified a mutation in the α-keratin gene KRT75 as the cause of the frizzle feather phenotype in chickens, characterized by a defective rachis and altered feather structure. This mutation involved a 69-bp in-frame deletion, leading to protein dysfunction and affecting keratin dimerization. The frizzle gene was transmitted in an autosomal incomplete dominant mode. Experimental approaches, including retroviral-mediated expression and misexpression studies, confirmed the mutation's impact on feather morphology, highlighting the role of α-keratins in feather development. The research suggested potential physiological effects of the mutation and emphasized the importance of genetic approaches in understanding feather morphology and evolution.
13 citations
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December 2018 in “Development, Growth & Differentiation” Sex hormones, especially estradiol, can change chicken feather shapes and colors.
3 citations
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October 2022 in “PloS one” Scientists have developed a method to keep chicken feather follicles alive and structurally intact in a lab for up to a week.
5 citations
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June 2015 in “Journal of Investigative Dermatology” Feathers are useful for researching growth, regeneration, and the effects of treatments like chemotherapy on hair loss.