Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

In this study, whole-genome sequencing of Lanping black-boned sheep identified ERBB4 and ROR1 genes as potentially important in their distinctive hyperpigmentation, enhancing understanding of their genetic evolution from Lanping normal sheep.

This pilot study found elevated levels of leptin and other proinflammatory molecules in the serum of melanoma patients, suggesting a potential role for leptin in melanoma progression and a possibility for targeting it in adjuvant therapy.

In this study, women with polycystic ovarian syndrome were found to have significantly higher blood levels of DHEA, IL-6, and TNF-α compared to healthy controls.

In this study, human dermal papilla cells exposed to wasabi leaf extract showed changes in cytokine-related gene expression, which the authors suggest could help clarify the biological effects of wasabi.

This study found that overexpressing Rps14 in supporting cells promoted hair cell regeneration in the organ of Corti by facilitating cell proliferation and differentiation.

The document concludes that various medications and treatments can have significant, sometimes adverse, effects on health outcomes.

This review discusses the effects of photobiomodulation, particularly its potential to reduce inflammation in various conditions, but it does not report new clinical findings.

This review introduces the morphological and molecular principles of hair follicle development but reports no new experimental results, focusing on recent insights and forming a working hypothesis.

This review discusses the roles of key developmental signaling pathways in mammalian skin repair compared to skin development, and suggests these insights could lead to better wound healing therapies, but it reports no new findings.

This study developed molecular signatures for dermal papilla cells and their niche, uncovering novel signaling regulators and genes linked to hair disorders, which may inform future hair development research.

This review discusses the biology and development of skin melanocytes, but reports no new clinical findings.

This study found that stabilized beta-catenin is crucial for activating stem cell transition from quiescence to proliferation in hair follicles by influencing gene expression within the stem cell niche.

This article discusses the rationale, design, and significant findings of the long-running Rotterdam Study but reports no new clinical results.

This study suggests that skin-derived precursors from Sox2(+) hair follicle dermal cells have the potential to function as dermal stem cells, supporting hair morphogenesis, dermal maintenance, and wound-healing.

This study found that super-enhancers are essential for hair follicle stem cell identity, lineage commitment, and plasticity in mice, with SOX9 being a key regulator of these chromatin dynamics.

This study found that in mice, inactivating beta-catenin in the dermal papilla reduces hair follicle progenitor proliferation and disrupts the hair cycle.

This study found that induced expression of mir-302 can reprogram human hair follicle cells into induced pluripotent stem cells through a novel epigenetic mechanism involving global demethylation.

In this study, researchers found that wound healing in mouse skin recruits diverse fibroblasts, including myeloid-derived cells, which contribute to regenerating adipocytes.

This review discusses mesenchymal–epithelial interactions in hair follicle development and cycling, highlighting recent insights without reporting new experimental results.

This article reviews the role of epithelial-mesenchymal interactions in hair follicle morphogenesis and the hair cycle, suggesting potential paths for developing treatments for hair growth disorders but providing no new clinical findings.

This study demonstrates that bioengineered lacrimal gland germs can successfully develop and restore tear production and ocular surface protection in a mouse model with lacrimal gland dysfunction.

This study found that fibroblast growth factor 9, initially secreted by γδ T cells, plays a key role in modulating hair follicle regeneration in mice after skin wounds.

This review discusses the role of epidermal and other adult stem cells in skin repair, focusing on their potential therapeutic applications for non-healing wounds and other skin disorders, but reports no new research results.

This article reviews the complex signaling pathways between epithelial and mesenchymal cells crucial for hair follicle morphogenesis, highlighting the Wnt pathway's role as a master regulator without reporting new experimental findings.

This study found that the BMP antagonist noggin induces hair growth in postnatal skin by neutralizing BMP4's inhibitory activity, potentially mediated by changes in Shh expression.

In this mouse study, researchers found that dermal Wnt signaling/β-catenin activity is essential for fibroblast proliferation and initiating hair follicle formation by interacting with epidermal Wnt ligands.

This review discusses advances in understanding mammalian stem cell niches, particularly in bone marrow, tooth, and hair follicle, and highlights the potential for developing therapies targeting these niches for tissue repair.

This article discusses the development of an evidence-based guideline for treating androgenetic alopecia and reports no new research results.

This study reviewed recent theories on alopecia areata's pathogenesis, highlighting its autoimmune nature due to immune privilege disruption in hair follicles, and noted current treatments have limited efficacy with high relapse rates, underscoring the need for further research into its mechanisms for better therapies.

This study found that polycomb-group-mediated repression plays a key role in regulating hair follicle stem cell states and lineage progression by distinct mechanisms in adult mouse skin.