Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that social isolation in rats enhanced the effects of ethanol on certain brain steroids, increased GABAA receptor subunits, and amplified ethanol's inhibitory effects on seizures.

This review suggests that GABAergic neuroactive steroids modulated by alcohol could play a role in vulnerability to alcohol use disorders, providing a rationale for further therapeutic exploration.

This study suggests that altering levels of the neurosteroid allopregnanolone during neonatal stages in rats may impact alcohol consumption and dopamine release in adulthood, indicating potential effects on alcohol reward properties.

Female mice are less affected by certain substances that alter alcohol consumption compared to male mice.

This study found that finasteride dose-dependently blocked the acquisition of ethanol drinking in mice and maintained reduced consumption even after treatment ended.

In this study, ethanol discontinuation in Y 1 R / LacZ transgenic mice significantly decreased neuropeptide Y immunoreactivity and increased Y 1 receptor gene expression in the amygdala, with evidence suggesting an important role for the progesterone metabolite 3α,5α‐TH PROG in these changes.

In this study, thalamic GABAA receptor α4 subunit levels were regulated after acute and chronic ethanol exposure, with temporal expression changes affected by phosphorylation state and neuroactive steroids.

This study found that acute finasteride treatment decreased ethanol intake in male C57BL/6J mice, whereas chronic treatment showed diminished effects, implying compensatory changes in neurosteroid modulation.

In this study, finasteride altered acute ethanol withdrawal severity differently in male and female mice, highlighting sex differences in sensitivity to changes in neurosteroid levels.

This review concludes that while many epidemiological studies suggest high alcohol intake is associated with an increased risk of prostate cancer, the evidence may be affected by confounding factors such as diet and lifestyle.

In this study, Alhanshali and co-authors reported that low-dose oral minoxidil, used for treating androgenetic alopecia, may worsen hangover symptoms in some male patients, potentially due to interactions with alcohol that affect blood pressure and metabolic processes.

This study found that Dansam-Samultang may promote hair growth and hair loss prevention in C57BL/6 mice, with notable improvements in hair follicle number, depth, and dermal thickness.

Global oil use will rise, US corn-to-ethanol policy is flawed, and various social and economic issues need attention.

The document concludes that the exact way alcohol causes harm to fetal development is unknown, but it significantly affects nutrient transport to the fetus and a safe level of alcohol during pregnancy is not determined.

This study found that Dansam-Samultang promoted hair growth and increased follicle number and depth in C57BL/6 mice, with effects similar to those of minoxidil.

This review discusses the pharmacological properties and physiological regulation of neuroactive steroids, focusing on their varied responses to stress and ethanol in rats, mice, and humans, but it reports no new findings.

Finasteride reduces alcohol withdrawal effects, especially in female mice.

In this study, 65% of men with persistent sexual side effects after stopping finasteride reported a reduction in alcohol consumption, echoing findings in rodent models.

This study found that progesterone pretreatment in rats potentiated the effect of ethanol on mesocortical dopamine levels, suggesting an influence of neuroactive steroids on ethanol's action.

In this study, socially defeated mice showed increased alcohol consumption, and CRF-R1 antagonism selectively reduced drinking in these mice, suggesting a potential treatment target for stress-related alcohol use disorders.

This study suggests that neurosteroids and compounds acting on GABA(A) receptors, like THIP, may modulate ethanol intake by influencing drinking patterns.

This article reviews the consumption patterns and historical use of Allium vegetables like onions and garlic for their potential antimicrobial and cardiovascular benefits, but reports no new clinical findings.

This study found that Allium ascalonicum L. extract may improve insulin resistance by increasing insulin tolerance test values and lowering blood glucose levels, though more research is needed to understand its effects on metabolic disorders.

This study found that finasteride affected ethanol withdrawal severity differently in WSP and WSR lines, with more modulation seen in the WSP line.

This study found that among premenopausal women taking flibanserin, consuming wine with an evening meal may increase the risk of syncope and orthostatic hypotension-related adverse events compared to placebo.

This study found that during the Covid-19 lockdown, the percentage of abstinent and low-risk alcohol drinkers increased while moderate and chronic drinking decreased compared to the previous four years.

This study characterized bioactive compounds in extracts from six Kalimantan herbal plants, confirming traditional medicinal uses with findings such as triterpenoids and several potent compounds with antimicrobial and cardiovascular benefits, laying groundwork for potential therapeutic applications and conservation efforts.

Progesterone increases alcohol tolerance and withdrawal anxiety, while DHEAS prevents them.

This study found that the estrous cycle influences the effect of the δ-GABAAR agonist THIP in reducing binge drinking behavior in female mice, with receptor expression elevated during diestrus.