Ethanol Intake Patterns in Female Mice: Influence of Allopregnanolone and the Inhibition of Its Synthesis

May 2008 in “ Drug and Alcohol Dependence ”

Matthew M. Ford, Ethan H. Beckley, Jeffrey D. Nickel, Sean R. Eddy, David P. Finn

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Research cited in this study

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research Inhibition of Progesterone Metabolism Mimics the Effect of Progesterone Withdrawal on Forced Swim Test Immobility

60 citations , June 2007 in “Pharmacology Biochemistry and Behavior”

research Sex Differences in the Effect of Finasteride on Acute Ethanol Withdrawal Severity in C57BL/6J and DBA/2J Mice

34 citations , April 2007 in “Neuroscience”

Finasteride reduces alcohol withdrawal severity in male mice but increases it in female mice.

research Finasteride Delays the Onset of Maternal Behavior in Primigravid Rats

19 citations , June 2006 in “Physiology & Behavior”

Finasteride slows down motherly behavior in first-time pregnant rats.

research A New Look at the 5-Alpha-Reductase Inhibitor Finasteride

137 citations , March 2006 in “Cns Drug Reviews”

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

Treatment With and Withdrawal From Finasteride Alter Ethanol Intake Patterns in Male C57BL/6J Mice: Potential Role of Endogenous Neurosteroids

research Treatment With and Withdrawal From Finasteride Alter Ethanol Intake Patterns in Male C57BL/6J Mice: Potential Role of Endogenous Neurosteroids

54 citations , August 2005 in “Alcohol”

Finasteride affects alcohol intake in male mice, possibly due to neurosteroids.

research Interaction of Chronic Ethanol Exposure and Finasteride: Sex and Strain Differences

29 citations , June 2004 in “Pharmacology, Biochemistry and Behavior”

Finasteride reduces alcohol withdrawal effects, especially in female mice.

research The role of pregnane neurosteroids in ethanol withdrawal: behavioral genetic approaches

83 citations , January 2004 in “Pharmacology & Therapeutics”

The study investigated the impact of pregnane neurosteroids, especially allopregnanolone (ALLOP), on ethanol withdrawal, emphasizing their interaction with GABAA receptors. It was observed that chronic ethanol exposure and withdrawal altered neurosteroid levels and sensitivity, with seizure-prone animals exhibiting reduced ALLOP levels and tolerance to its anticonvulsant effects. Adjusting ALLOP levels using finasteride lessened withdrawal severity. Genetic research indicated interactions between GABAA receptor subunits and the enzyme 5α-reductase, suggesting that neurosteroid biosynthesis could be a therapeutic target for alcohol dependence. The study underscored the potential of neurosteroid treatment during ethanol withdrawal and proposed that genetic variations might affect withdrawal severity.