22 citations
,
January 2001 in “Chemical & Pharmaceutical Bulletin” This study found that two new progesterone derivatives showed higher antiandrogenic effects and 5α-reductase inhibition than finasteride in hamsters, particularly reducing seminal vesicle weight and flank organ size.
21 citations
,
January 2012 in “Annals of Dermatology” This study reported that Ell-Cranell® alpha 0.025% solution significantly increased hair counts and diameter in Korean women with female pattern hair loss over an 8-month period, showing both efficacy and safety.
20 citations
,
November 2015 in “International Journal of Gynecology & Obstetrics” Among women with polycystic ovary syndrome, this study found that oral contraceptives containing 20 μg ethinyl estradiol had similar effects on androgen levels as those containing 30 μg.
18 citations
,
March 2010 in “Gynecologic and obstetric investigation” This study found that both combined therapy with goserelin and oral contraceptives, and oral contraceptives alone, significantly reduced hair diameter in severe hirsutism without a significant difference between treatments.
16 citations
,
January 2019 in “Neuropsychobiology” This study found that individuals with lichen planopilaris reported lower quality of life and self-esteem and higher depression scores compared to healthy controls.
15 citations
,
July 2021 in “JAMA Dermatology” This study found that androgenetic alopecia is significantly associated with moderate impairment of health-related quality of life and emotions, but not with depressive symptoms.
14 citations
,
October 2015 in “Neurochemistry International” This study found that letrozole, an aromatase inhibitor, reduced the incidence and severity of PTZ-induced kindling seizures in mice, potentially due to its effects on 17β-estradiol and neurosteroid synthesis.
14 citations
,
June 2011 in “Steroids” This study found that several dehydroepiandrosterone ester derivatives effectively reduced prostate and seminal vesicle weight in gonadectomized hamsters treated with testosterone, demonstrating potential antiandrogen effects comparable to Finasteride.
13 citations
,
September 2010 in “Journal of Dermatological Science” Researchers made a cell line that grows quickly and can help with hair growth research.
13 citations
,
January 2005 in “Chemical and Pharmaceutical Bulletin” This study reported that newly synthesized progesterone derivatives significantly reduced prostate weight in testosterone-treated hamsters, with 5alpha-reductase inhibitory activity dependent on the size of the substituent at C-17.
12 citations
,
December 2018 in “Journal of Cosmetic Dermatology” In this study, hair transplantation was found to significantly improve self-esteem and satisfaction with appearance among male androgenetic alopecia patients.
11 citations
,
April 2017 in “The European Journal of Contraception & Reproductive Health Care” This review highlights that Cyproterone acetate combined with ethinylestradiol is highly effective for treating severe acne and hirsutism in women with hyperandrogenism, and it also provides benefits for cycle control and mood improvement, according to the analysis of 78 studies.
9 citations
,
July 2007 in “PubMed” This study found that both Finasteride and high-dose Atrazine induced hypospadias in male SD rats, establishing a reproducible animal model for this condition.
7 citations
,
October 1974 in “PubMed” In this study, topical estrogens and corticosteroids were associated with decreased telogen rates in 52% of androgenetic alopecia patients, suggesting potential clinical improvement, though the role of corticosteroids remains unclear.
6 citations
,
January 2017 in “Annals of Dermatology” In this study, Korean women with female pattern hair loss who used a combination of topical 0.025% 17α-estradiol and 3% minoxidil saw significant increases in total hair count and hair caliber over six months.
6 citations
,
April 2004 in “Journal of Enzyme Inhibition and Medicinal Chemistry” This study found that four new progesterone derivatives reduced prostate weight in gonadectomized hamsters, suggesting potent in vivo antiandrogenic effects similar to finasteride.
5 citations
,
November 2015 in “Journal of Enzyme Inhibition and Medicinal Chemistry” This study found that aliphatic ester moieties in 16-formyl-17-methoxy dehydroepiandrosterone derivatives increased their potency as 5α-reductase type 2 inhibitors in vitro compared to finasteride.
5 citations
,
November 2009 in “Revista médica de Chile” This study confirms that scalp hair follicles in Chilean subjects exhibit seasonal variations, with a higher percentage of follicles in the telogen (resting) phase during the summer compared to the winter.
5 citations
,
January 2007 in “Immunopharmacology and Immunotoxicology” This study found that 17beta-estradiol enhanced allergy responses in certain age groups of female mice and inhibited thymus involution and regeneration after contact hypersensitivity.
3 citations
,
February 2019 in “The European Research Journal” In this study, self-esteem, body image, and sexual function in women significantly improved after total laser pubic hair removal.
3 citations
,
January 2012 This study developed and validated an RP-HPLC-PDA method for accurately estimating Tamsulosin and Finasteride in bulk and tablet forms, achieving precise detection and linearity within specified concentration ranges.
3 citations
,
September 1989 in “Journal of Investigative Dermatology” This study found that methyl nonanoate and methyl caprate significantly enhanced the skin penetration of minoxidil compared to solutions with other common enhancers like Azone, DMSO, or DEET.
2 citations
,
April 2022 in “Nusantara Bioscience” This study proposes a quick and sensitive method for detecting vancomycin using modified silver nanoparticles and shows promising results against Gram-positive and Gram-negative bacteria.
2 citations
,
December 2018 in “Natural Product Research” This study identified a new compound from fermented Carica papaya L. with moderate antioxidant and potent hair growth-stimulating activities in vitro.
1 citations
,
February 2026 in “Journal of the American Academy of Dermatology” 1 citations
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February 2023 in “Arquivos de Ciências da Saúde da UNIPAR” This review discusses various non-surgical aesthetic treatments for hair loss and concludes that these treatments are evolving and show potential for improving self-esteem through hair regrowth, but more research is needed.
January 2026 in “Frontiers in Cellular Neuroscience” This study discusses the complex roles and effects of brain-synthesized sex neurosteroids, highlighting sex differences in their concentrations and their varied impacts on synaptic plasticity, cognitive behavior, and aging-related cognitive decline.
June 2006 in “Annales de Dermatologie et de Vénéréologie” This review highlights the potential benefits of spironolactone in dermatology, particularly for female acne, supporting its safety over long-term use without extensive testing, but presents no new clinical results.
June 2026 in “Revista Ibero-Americana de Humanidades, Ciências e Educação” This study highlights the crucial role pharmacists play in the aesthetic field, emphasizing their technical knowledge in ensuring safe and informed use of cosmetic products, which enhances professional recognition and promotes more secure and ethical aesthetic practices.
August 2025 in “International Journal of Science and Research (IJSR)” This study, conducted at a tertiary care center in India, found a high prevalence of vitamin D deficiency and insufficiency among patients with alopecia areata, though no statistically significant correlation between vitamin D levels and disease severity or duration was observed.