17β-Estradiol Enhances Contact Hypersensitivity in a Hair Cycle-Dependent Manner and Retards Thymic Atrophy with Age

    January 2007 in “ Immunopharmacology and Immunotoxicology ”
    Fumitoshi Sakazaki, Hitoshi Ueno, Katsuhiko Nakamuro
    TLDR 17β-Estradiol boosts allergic reactions and slows thymus aging in mice.
    The study investigated the effects of 17β-estradiol on contact hypersensitivity and thymic atrophy in relation to the hair cycle. It was found that 17β-estradiol enhanced contact hypersensitivity in a manner dependent on the hair cycle phase. Additionally, the hormone was observed to retard age-related thymic atrophy. These findings suggested that 17β-estradiol played a role in modulating immune responses and aging processes, potentially offering insights into therapeutic approaches for conditions related to immune function and aging.
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