17β-Estradiol Enhances Contact Hypersensitivity in a Hair Cycle-Dependent Manner and Retards Thymic Atrophy with Age

January 2007 in “ Immunopharmacology and Immunotoxicology ”

Fumitoshi Sakazaki, Hitoshi Ueno, Katsuhiko Nakamuro

TLDR 17β-Estradiol boosts allergic reactions and slows thymus aging in mice.

The study investigated the effects of 17β-estradiol (E2) on contact hypersensitivity (CHS), thymic atrophy, and hair-cycle changes in female mice. E2 was found to enhance allergic reactions in 3- and 7-week-old mice, coinciding with periods just before hair regrowth. Additionally, E2 treatment repressed age-related thymic atrophy compared to controls, and while E2 alone did not cause thymus involution, it inhibited thymus involution and supported regeneration following CHS.

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