Local Synthesis and Function of Neuro-Estrogen and Neuro-Androgen: Impact on Hippocampus-Related Cognition and Neuronal Plasticity

    January 2026 in “ Frontiers in Cellular Neuroscience ”
    S. Kawato, Yasushi Hojo, Mika Soma … Mari Ogiue-Ikeda
    Studysummary This study discusses the complex roles and effects of brain-synthesized sex neurosteroids, highlighting sex differences in their concentrations and their varied impacts on synaptic plasticity, cognitive behavior, and aging-related cognitive decline.
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    Research cited in this study 6

    1. Locally Synthesized 17-Beta-Estradiol Reverses Amyloid-Beta-42-Induced Hippocampal Long-Term Potentiation Deficits International journal of molecular sciences · 2024
    2. Neurosteroids in Adult Hippocampus of Male and Female Rodents: Biosynthesis and Actions of Sex Steroids Frontiers in endocrinology · 2018
    3. Rapid Nongenomic Modulation by Neurosteroids of Dendritic Spines in the Hippocampus: Androgen, Estrogen, and Corticosteroid Journal of neuroendocrinology · 2017
    4. Different Synaptic Stimulation Patterns Influence Local Androgenic and Estrogenic Neurosteroid Availability Triggering Hippocampal Synaptic Plasticity in Male Rats European journal of neuroscience/EJN. European journal of neuroscience · 2017
    5. Neo-Synthesis of Estrogenic or Androgenic Neurosteroids Determine Whether Long-Term Potentiation or Depression Is Induced in Hippocampus of Male Rat Frontiers in Cellular Neuroscience · 2015
    6. Cognitive Effects of Testosterone and Finasteride Administration in Older Hypogonadal Men PubMed · 2014