Cognitive Effects of Testosterone and Finasteride Administration in Older Hypogonadal Men

August 2014 in “ PubMed ”

Stephen E. Borst, Joshua F. Yarrow, Carmen Fernandez, Christine F. Conover, Fan Ye, John R. Meuleman, Matthew P. Morrow, Baiming Zou, Jonathan J. Shuster

testosterone finasteride testosterone replacement therapy hypogonadism Propecia TRT

TLDR Testosterone improves mood and thinking skills; finasteride has no effect.

The study investigated the cognitive effects of testosterone and finasteride administration in older hypogonadal men. The results showed that testosterone administration produced small improvements in depressive symptoms and visuospatial cognition, while finasteride administration did not have any significant effects on cognitive function. The study suggests that testosterone replacement therapy may have cognitive benefits for older men with hypogonadism, but further research is needed to explore the potential benefits in other cognitive domains.

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Research cited in this study

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Exogenous Testosterone Alone or With Finasteride Does Not Improve Measurements of Cognition in Healthy Older Men With Low Serum Testosterone

research Exogenous Testosterone Alone or With Finasteride Does Not Improve Measurements of Cognition in Healthy Older Men With Low Serum Testosterone

77 citations, November 2007 in “International Journal of Andrology”

Testosterone with or without finasteride doesn't improve thinking skills in older men with low testosterone.

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Related Research

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research Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men

30 citations, August 1992 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride doesn't affect hormone levels in normal men.