56 citations,
May 2017 in “Nature Cell Biology” Hair can regrow after certain stem cells are lost because other stem cells can take over their role.
222 citations,
August 2009 in “Experimental Dermatology” Stem cells are crucial for wound healing and understanding their role could lead to new treatments, but more research is needed to answer unresolved questions.
10 citations,
August 2021 in “EMBO Reports” The Bcl-2 protein is important for keeping hair follicle stem cells working and preventing hair loss.
11 citations,
June 2021 in “Frontiers in Cell and Developmental Biology” Melatonin helps goat hair stem cells grow and maintain their ability to become different cell types.
60 citations,
April 2012 in “Physiology” The document concludes that understanding hair and feather regeneration can help develop new regenerative medicine strategies.
2 citations,
January 2014 in “Hair therapy & transplantation” New treatments for hair growth disorders are needed due to limited current options and complex hair follicle biology.
January 2024 in “Journal of cellular immunology” Hair follicle stem cells are important for maintaining healthy skin and interact with many signals.
2 citations,
August 2023 in “Development” Hair follicles in the back of the rosette fancy mouse have reversed orientations due to a gene mutation.
10 citations,
January 2013 in “Journal of skin cancer” PKC ε increases hair follicle stem cell turnover and may raise skin cancer risk.
February 2024 in “Frontiers in physiology” Hair follicle stem cells help skin heal and grow during stretching.
2 citations,
June 2022 in “Scientific reports” Mouse hair follicle stem cells lose their ability to change into different cell types after being grown for a long time.
December 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” MicroRNA-205 helps hair grow by changing the stiffness and contraction of hair follicle cells.
13 citations,
December 2017 in “Stem cells” Low-dose radiation affects hair stem cell function and survival by changing their genetic material's structure.
November 2023 in “Frontiers in cell and developmental biology” Hair aging is caused by stress, hormones, inflammation, and DNA damage affecting hair growth and color.
18 citations,
December 2018 in “Expert Opinion on Biological Therapy” Hair follicle stem cells are promising for wound healing but require more research for safe clinical use.
January 2024 in “Pharmacy information” New treatments using stem cells and other methods show promise for promoting hair growth in androgenetic alopecia.
95 citations,
May 2012 in “British Journal of Dermatology” Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.
January 2020 in “Egyptian Journal of Dermatology and Venereology” People with alopecia have shorter hair follicles and more c-kit, a stem cell factor receptor, which could predict how the condition progresses.
4 citations,
March 2022 in “Pharmaceutics” Regenerative cellular therapies show promise for treating non-scarring hair loss but need more research.
39 citations,
October 2013 in “Plastic and Reconstructive Surgery” Human alpha defensin 5 helps heal wounds, reduce bacteria, and grow hair on burned skin.
14 citations,
April 2011 in “Cell Proliferation” Scientists can grow human hair follicle stem cells in a lab without changing their nature, which could help treat hair loss.
66 citations,
July 2015 in “Organogenesis” Wnt signaling is crucial for skin wound healing and reducing scars.
September 2023 in “Frontiers in medicine” The mTOR signaling pathway is crucial for hair health and targeting it may lead to new hair loss treatments.
11 citations,
July 2016 in “Current Opinion in Cell Biology” New techniques have enhanced our understanding of how stem cells function and the role of mutations in aging tissues, which may influence future cancer therapies.
61 citations,
December 2016 in “The EMBO Journal” The study showed that hair follicle stem cells can maintain and organize themselves in a lab setting, keeping their ability to renew and form hair and skin.
20 citations,
August 2014 in “PloS one” MED1 affects skin wound healing differently in young and old mice.
62 citations,
November 2009 in “Aging Cell” Hedgehog signaling helps keep hair follicle stem cells the same in both young and old human skin.
11 citations,
March 2014 in “Journal of Investigative Dermatology” Genetic mutation and carcinogen treatment are both needed for skin cancer to develop in these specific mice.
23 citations,
May 2013 in “Virology” HPV16 oncogenes disrupt the normal activity of hair follicle stem cells.
47 citations,
October 2016 in “Molecular and Cellular Endocrinology” Androgens prevent hair growth by changing Wnt signals in cells.