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    Glossary Epidermal Growth

    process of skin's outer layer regenerating and repairing itself

    Epidermal growth refers to the process by which the outermost layer of the skin, known as the epidermis, regenerates and repairs itself. This involves the proliferation and differentiation of keratinocytes, the primary cell type in the epidermis, which move from the basal layer to the surface, eventually forming a protective barrier. This process is crucial for wound healing and maintaining skin integrity.

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    1. Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure. The EMBO Journal · 1995 · 252 citations
    2. Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes Molecular and Cellular Biology · 2006 · 226 citations
    3. Follicular and epidermal alterations in patients treated with ZD1839 (Iressa), an inhibitor of the epidermal growth factor receptor 2002 · 169 citations
    4. Effects of in vivo-administered 2,3,7,8-tetrachlorodibenzo-p-dioxin on receptor binding of epidermal growth factor in the hepatic plasma membrane of rat, guinea pig, mouse, and hamster. Proceedings of the National Academy of Sciences · 1984 · 164 citations
    5. Classification and management of skin, hair, nail and mucosal side-effects of epidermal growth factor receptor (EGFR) inhibitors European journal of cancer · 2007 · 138 citations
    6. Distribution and number of epidermal growth factor receptors in skin is related to epithelial cell growth Developmental Biology · 1983 · 124 citations
    7. Cutaneous Side Effects in Non-Small Cell Lung Cancer Patients Treated with Iressa (ZD1839), an Inhibitor of Epidermal Growth Factor Acta Dermato Venereologica · 2003 · 116 citations
    8. Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development. PubMed · 1997 · 107 citations
    9. Recent advances in the epidermal growth factor receptor/ligand system biology on skin homeostasis and keratinocyte stem cell regulation Journal of Dermatological Science · 2013 · 97 citations
    10. Epidermal Growth Factor as a Biologic Switch in Hair Growth Cycle 2003 · 94 citations
    11. The PRIDE (Papulopustules and/or paronychia, Regulatory abnormalities of hair growth, Itching, and Dryness due to Epidermal growth factor receptor inhibitors) syndrome British Journal of Dermatology · 2006 · 90 citations
    12. EFFECTS OF EPIDERMAL GROWTH FACTOR ON HAIR GROWTH IN THE MOUSE Journal of Endocrinology · 1981 · 84 citations
    13. Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16 Stem Cells and Development · 2016 · 83 citations
    14. Epidermal growth factor delays the development of the epidermis and hair follicles of mice during growth of the first coat The Anatomical Record · 1983 · 72 citations
    15. Epidermal Growth Factor Receptor Inhibitors: A Review of Cutaneous Adverse Events and Management Dermatology research and practice · 2014 · 68 citations
    16. 2,3,7,8‐Tetrachlorodibenzo‐<i>p</i>‐dioxin causes an increase in protein kinases growth hepatic associated with epidermal factor receptor in the plasma membrane Journal of Biochemical Toxicology · 1988 · 60 citations
    17. Safety Profile of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: A Disproportionality Analysis of FDA Adverse Event Reporting System Scientific Reports · 2020 · 58 citations
    18. Effects of epidermal growth factor, fibroblast growth factor, minoxidil and hydrocortisone on growth kinetics in human hair bulb papilla cells and root sheath fibroblasts cultured in vitro Archives of Dermatological Research · 1987 · 58 citations
    19. Nonscarring inflammatory alopecia associated with the epidermal growth factor receptor inhibitor gefitinib Journal of the American Academy of Dermatology · 2006 · 57 citations
    20. Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice Cancer Research · 2009 · 53 citations
    21. Aberrant expression of epidermal growth factor receptor in aural cholesteatoma The Laryngoscope · 1993 · 48 citations
    22. Epidermal Growth Factor Promotes Proliferation and Migration of Follicular Outer Root Sheath Cells via Wnt/β-Catenin Signaling Cellular physiology and biochemistry · 2016 · 43 citations
    23. Dermatological side effects of epidermal growth factor receptor inhibitors: ′Pride′ complex Indian Journal of Dermatology · 2014 · 43 citations
    24. The Cutaneous Epidermal Growth Factor Network: Can it be Translated Clinically to Stimulate Hair Growth? Dermatology Online Journal · 2009 · 39 citations
    25. Fibroblast growth factor and epidermal growth factor in hair development 1993 · 39 citations
    26. Semiology of skin toxicity associated with epidermal growth factor receptor (EGFR) inhibitors Supportive Care in Cancer · 2012 · 38 citations
    27. Epidermal growth factor promotes proliferation of dermal papilla cells via Notch signaling pathway Biochimie · 2016 · 36 citations
    28. Effects of Intradermally Injected and Topically Applied Mouse Epidermal Growth Factor on Wool Growth, Skin and Wool Follicles of Merino Sheep Australian Journal of Biological Sciences · 1988 · 36 citations
    29. A case report of inflammatory nonscarring alopecia associated with the epidermal growth factor receptor inhibitor erlotinib Journal of Cutaneous Pathology · 2009 · 33 citations
    30. Epidermal Growth Factor Upregulates Production of Supernumerary Hair Cells in Neonatal Rat Organ of Corti Explants Acta Oto-Laryngologica · 2000 · 33 citations