Mitigation of Epidermal Growth Factor Receptor Inhibitor-Induced Side Effects Utilizing Melanin and Vascular-Specific Lasers: A Case Report Series

The study explored the use of melanin and vascular-specific lasers to treat skin side effects in three stage III or IV cancer patients caused by epidermal growth factor receptor (EGFR) inhibitors. Two patients experienced a reduction in papulopustular eruptions after pulse dye laser (PDL) treatment, and two patients saw reduced hair growth following intense pulsed light (IPL) and/or Alexandrite laser treatments. One patient treated with both PDL and IPL reported improvements in both EGFR-induced hypertrichosis and papulopustular eruptions. The findings suggested that laser and light devices targeting melanin and hemoglobin could effectively mitigate cutaneous adverse effects in patients unresponsive to traditional therapies, offering a new treatment option for managing chemotherapy-induced side effects.