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Mice with human fetal thymic tissue and stem cells developed symptoms similar to chronic graft-versus-host disease.

Thiopurines help treat IBD but require genetic testing to avoid side effects.

Early diagnosis and hormone therapy can significantly improve outcomes for post-partum pituitary insufficiency in resource-limited settings.

PFOS exposure disrupts hormone levels and enzyme activities in juvenile frogs, affecting males and females differently.

High ornithine decarboxylase levels may lead to hair loss and cancer by increasing CK2 activity in the nucleus.

The system allows precise control of gene expression in mouse skin, useful for studying skin biology.

Cell-based models help test if cosmetic ingredients really work for hair growth and skin health.

Understanding how androgens work is key for creating new treatments for prostate issues and hair/skin conditions.

New liposome treatment successfully delivers CRISPR to deactivate a key enzyme in androgen-related disorders.

Low androgen levels can still cause female pattern hair loss.

Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.

Mutations in the enzyme don't significantly change how it binds to its specific substances.

Four-amino acid part makes enzyme sensitive to finasteride.

Finasteride increases hair growth, prolongs hair cycle, and lowers dihydrotestosterone levels.

High doses of testosterone disrupt hormone levels and receptor expression in the uterus, affecting fertility.

Blocking DHT production more strongly may help control advanced prostate cancer and improve quality of life.

Glycine reduces skin pigmentation by lowering melanin production.

Cystatin M/E strongly inhibits cathepsin V and cathepsin L, important for skin formation.

Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.

Glycerol is essential for skin hydration in mice without sebaceous glands.

Blocking androgen activity in newborn rats affects body weight and appetite-related hormones differently in males and females.

Hormonal interactions, especially involving DHT and estrogen, play a key role in BPH development and treatment.

Minoxidil helps hair growth by activating enzymes in hair follicles.

Scientists identified three genes important for processing certain brain chemicals, thyroid hormones, and medications.

Cepharanthine may help hair growth by increasing IGF-I in scalp cells.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Finasteride effectively blocks rat enzymes, but with varying methods and strength.

Human platelets change minoxidil to minoxidil sulfate, helping blood vessels widen.

Effective hirsutism management requires identifying the cause, combining new and traditional treatments, and setting realistic expectations for patients.

The effects of estrogen on human scalp hair growth are unclear and need more research.