Hallmark Evidence of Lipopolysaccharide Tolerance in Obese Women with Polycystic Ovary Syndrome: LPS-Induced NFkB Suppression in Mononuclear Cells Linked to Hyperandrogenism

The study examined the impact of preconception testosterone (T) and anti-Müllerian hormone (AMH) levels on neonatal health outcomes in 583 women without PCOS. Participants were categorized into four groups: low T/low AMH (n=358), low T/high AMH (n=89), high T/low AMH (n=75), and high T/high AMH (n=61). Findings indicated that babies born to mothers with high T/high AMH levels had a nearly doubled risk of NICU admission (20.3%) compared to those with low T/low AMH levels (9.4%; RR: 1.85, 95%CI: 0.97, 3.53). No significant differences were observed in birthweight, multiple birth rate, gestational diabetes incidence, preterm or early term birth rates, or 5-minute Apgar scores < 7 across the groups. The study concluded that elevated preconception T and AMH levels are associated with an increased risk of adverse neonatal outcomes, specifically NICU admissions, suggesting a need for further research into the hormonal factors linked to PCOS that may affect neonatal health.