Search

for
Search:

GlossaryEpidermal Growth Factor (EGF)

stimulates cell growth and healing in skin and hair

Epidermal Growth Factor (EGF) is a protein that stimulates cell growth, proliferation, and differentiation by binding to its receptor, EGFR. It plays a crucial role in the healing of wounds and the regeneration of skin and hair follicles. EGF is often used in skincare products to promote skin repair and reduce signs of aging.

Related Terms

Sort by

Research

30 / 1000+ results

research Classification and Management of Skin, Hair, Nail, and Mucosal Side Effects of Epidermal Growth Factor Receptor Inhibitors

138 citations, February 2007 in “European journal of cancer”

EGFR inhibitors often cause skin problems and other side effects, but these are usually reversible and can be managed to keep patients comfortable.

research Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles

94 citations, February 1994 in “The journal of investigative dermatology/Journal of investigative dermatology”

EGF makes hair follicles grow longer but stops hair production.

research KGF And EGF Signaling Block Hair Follicle Induction And Promote Interfollicular Epidermal Fate In Developing Mouse Skin

82 citations, May 2009 in “Development”

EGF and KGF signalling prevent hair follicle formation and promote skin cell development in mice.

research Semiology of Skin Toxicity Associated with Epidermal Growth Factor Receptor Inhibitors

38 citations, February 2012 in “Supportive Care in Cancer”

Skin problems like acne, dry skin, and nail and hair changes are common in patients taking EGFR inhibitors.

research Erosive Pustular Dermatosis of the Scalp-Like Eruption Due to Gefitinib: Case Report and Review of Alopecia Associated with EGFR Inhibitors

36 citations, January 2012 in “Dermatology”

Stopping gefitinib improved scalp condition in a woman with lung cancer.

research IL-36γ Drives Skin Toxicity Induced by EGFR/MEK Inhibition and Commensal Cutibacterium Acnes

32 citations, December 2019 in “The Journal of clinical investigation/The journal of clinical investigation”

A protein called IL-36γ causes skin side effects from certain cancer treatments when combined with a common skin bacteria.

research The Management of EGFR Inhibitor Adverse Events: A Case Series and Treatment Paradigm

32 citations, January 2012 in “International Journal of Dermatology”

Skin side effects from EGFR inhibitor cancer treatment can be managed effectively, often without stopping the medication.

research EGFR Inhibitors and Cutaneous Complications: A Practical Approach to Management

29 citations, September 2017 in “Oncology and therapy”

The document provides advice on how to recognize and treat skin-related side effects of cancer drugs known as EGFR inhibitors.

research Suppression of Wnt/β-Catenin Signaling by EGF Receptor Is Required for Hair Follicle Development

25 citations, September 2018 in “Molecular Biology of the Cell”

Blocking Wnt/β-catenin signaling with EGF receptor is necessary for proper hair growth.

research Rash from EGFR Inhibitors: Opportunities and Challenges for Palliation

18 citations, July 2008 in “Current Oncology Reports”

EGFR cancer drugs often cause a rash, which can lead to distress and isolation, but may also improve outcomes for some cancer patients. Current treatments for the rash are limited, but a compound called menadione shows promise.

research EGFR Controls Hair Shaft Differentiation in a p53-Independent Manner

13 citations, April 2019 in “iScience”

EGFR helps control how hair grows and forms without needing p53 protein.

research Hair Growth Is Promoted by BeauTop via Expression of EGF and FGF-7

7 citations, April 2018 in “Molecular Medicine Reports”

BeauTop helps hair grow by increasing certain growth factors.

research The Role of the VEGF, KGF, EGF, and TGF-β1 Growth Factors in the Pathogenesis of Telogen Effluvium in Women

5 citations, March 2017 in “Biomedical and Pharmacology Journal”

Certain growth factors significantly affect hair loss in women with telogen effluvium.

Cutaneous Lymphadenoma Is a Distinct Trichoblastoma-like Lymphoepithelial Tumor With Diffuse Androgen Receptor Immunoreactivity, Notch1 Ligand in Reed-Sternberg-like Cells, and Common EGFR Somatic Mutations

research Cutaneous Lymphadenoma Is a Distinct Trichoblastoma-like Lymphoepithelial Tumor With Diffuse Androgen Receptor Immunoreactivity, Notch1 Ligand in Reed-Sternberg-like Cells, and Common EGFR Somatic Mutations

4 citations, May 2021 in “The American Journal of Surgical Pathology”

Cutaneous Lymphadenoma is a unique skin tumor with specific protein markers and common gene mutations that may cause continuous cell growth.

research Treatment of Cultured Sebocytes with an EGFR Inhibitor Does Not Lead to Significant Upregulation of Inflammatory Biomarkers

3 citations, January 2011 in “Annals of Dermatology”

Blocking EGFR in skin cells doesn't majorly increase inflammation markers.

research BFNB Enhances Hair Growth in C57BL/6 Mice Through the Induction of EGF and FGF7 Factors and the PI3K-AKT-Beta-Catenin Pathway

2 citations, July 2023 in “International Journal of Molecular Sciences”

BFNB could be a promising treatment for hair growth.

Sustained Release of EGF/bFGF Growth Factors by Mussel-Inspired Core-Shell Nanofibers with Hemostatic and Anti-Inflammatory Effects for Promoting Wound Healing

research Sustained Release of EGF/bFGF Growth Factors by Mussel-Inspired Core-Shell Nanofibers with Hemostatic and Anti-Inflammatory Effects for Promoting Wound Healing

2 citations, March 2023 in “European Polymer Journal”

The new nanofiber improves wound healing by releasing growth factors, reducing inflammation, and helping skin regeneration.

research Hair Follicle Development of Rex Rabbits Is Regulated Seasonally by Wnt10b/β-Catenin, TGFβ-BMP, IGF1, and EGF Signaling Pathways

1 citations, December 2023 in “Animals”

Winter provides the best fur quality for Rex rabbits due to seasonal changes in specific signaling pathways.

research Different Levels of EGF, VEGF, IL-6, MCP-1, MCP-3, IP-10, Eotaxin, and MIP-1α in the Adipose-Derived Stem Cell Secretome in Androgenetic Alopecia

1 citations, February 2022 in “Experimental Dermatology”

Certain proteins are found at higher levels in balding areas compared to non-balding areas, suggesting a link to hair loss. This could be useful for diagnosing and treating hair loss.

research EGFR Marks a Subpopulation of Dermal Mesenchymal Cells Highly Expressing IGF1 Which Enhances Hair Follicle Regeneration

1 citations, May 2023 in “PubMed”

A certain type of skin cell, marked by EGFR, produces a lot of IGF1 and helps hair follicles grow back faster.

research Evaluation of Serum Levels of Epidermal Growth Factor in Patients with Alopecia Areata

July 2020 in “Benha Journal of Applied Sciences”

People with alopecia areata have higher levels of EGF in their blood than healthy people.

research MIG6 Is MEK-Regulated and Affects EGF-Induced Migration in Mutant NRAS Melanoma

April 2016 in “Journal of Investigative Dermatology”

Decreasing MIG6 can increase the movement and invasiveness of MEK-inhibited mutant NRAS melanoma, particularly when stimulated by EGF.

Cutaneous and Mucosal Side Effects of New Anticancer Drugs: EGF-R Inhibitors, Tyrosine Kinase Inhibitors, and Mitotic Spindle Stabilizers

research Cutaneous and Mucosal Side Effects of New Anticancer Drugs: EGF-R Inhibitors, Tyrosine Kinase Inhibitors, and Mitotic Spindle Stabilizers

January 2011

New cancer drugs can cause skin side effects like rashes, dry skin, hair changes, and nail problems.

research Scarring Hair Follicle Destruction Is Driven by the Collapse of EGFR-Protected JAK-STAT1-Sensitive Stem Cell Immune Privilege

October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

A protein called EGFR protects hair follicle stem cells, and when it's disrupted, hair follicles can be damaged, but blocking certain pathways can restore hair growth.

research Scarring Alopecia Is Driven by the Collapse of EGFR-Protected JAK-STAT1-Sensitive Stem Cell Immune Privilege

November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Cancer treatment drugs can cause permanent hair loss by damaging hair follicle stem cells, but a specific inhibitor might reverse this effect.

research Folliculitis Decalvans-Like Alopecia During EGFR Inhibitors Treatment for Lung Cancer: A Case Series of 6 Patients

July 2023 in “Dermatology practical & conceptual”

Some lung cancer patients treated with EGFR inhibitors may develop a hair loss condition similar to folliculitis decalvans.

research Single-Cell Transcriptomic Profile of EGFR-Deficient Epidermal Compartments During Folliculitis

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

EGFR deficiency causes significant changes in skin cells and hair follicles.

research Y27632 Promotes Proliferation via EGFR Signaling in a Newly Isolated and Characterized Human Primary Sebocyte Cell Line

April 2019 in “Journal of Investigative Dermatology”

Y27632 increases cell growth through EGFR signaling, not ROCK1/2.

research Epidermal Keratinocytes Regulate Bacterial Immune Responses and Host Defense Through EGFR

September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

EGFR inhibitors cause skin issues and hair loss by weakening skin defenses, suggesting antibiotics and targeted treatments can help.

research Mario Lacouture: How Do I Treat a Patient with Dermatologic Toxicities to EGFR Inhibitors?

June 2011 in “Oncology times”

Dr. Mario Lacouture recommends preventive and specific treatments for skin side effects caused by EGFR inhibitors to improve patients' quality of life.