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New CRISPR/Cas9 variants and nanotechnology-based delivery methods are improving cancer treatment, but choosing the best variant and overcoming certain limitations remain challenges.

The document concludes that there are no effective clinical treatments for hearing loss due to hair cell damage, but research is ongoing.

Polydeoxyribonucleotide (PDRN) may help lighten skin and treat hyperpigmentation.

Treating alopecia areata every 3 weeks with diphenylcyclopropenone is more effective than weekly treatments.

The document concludes that systemic autoimmune diseases are complex, incurable, and require ongoing treatment and research.

People with alopecia areata have much lower Vitamin-D levels than healthy individuals.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Cancer can hijack the body's cell repair system to promote tumor growth, and targeting this process may improve cancer treatments.

Mutations in the KRT85 gene cause hair and nail problems.

ROOT HAIR SPECIFIC 10 (RHS10) reduces the length of root hairs in Arabidopsis plants.

High energy boosts root hair growth in plants, while low energy stops it.

HO-1 helps skin health and healing but can worsen melanoma; it's a potential treatment target for skin diseases.

Chitosan slows root hair growth and causes a buildup of callose at low concentrations, but at high concentrations, it only inhibits growth without callose buildup.

SOX4 is crucial for the development of melanoma.

Certain immune cells in the skin release a protein that stops hair growth by keeping hair stem cells inactive.

CD8+ T cells are involved in alopecia areata and may cause disease relapse.

Mast cells and CD8 T cells interact closely in skin diseases, affecting each other's behavior and contributing to conditions like psoriasis and eczema.

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

Different small areas within hair follicles send specific signals that control what type of cells stem cells become.

The study identified unique genes in hair follicle cells and their environment, suggesting these genes help organize cells for hair growth.

Hair follicle cells age faster and lose pigment due to less catalase, causing hair to turn gray.

The review suggests that other immune cells besides CD8+ T cells may contribute to alopecia areata and that targeting regulatory cell defects could improve treatment.

Stress in hair follicle stem cells causes inflammation in a chronic skin condition through a specific immune response pathway.

Vitamin D made by the skin plays a role in immune defense and skin health, and more research is needed to understand its full effects.

A certain signaling pathway in mice, when increased, causes hair to gray by depleting the cells that give hair its color.

Hair and skin healing involve complex cell interactions controlled by specific molecules and pathways, and hair follicle cells can help repair skin wounds.

White blood cells and their traps can slow down the process of new hair growth after a wound.

The research showed how melanocytes develop, move, and respond to UV light, and their stem cells' role in hair color and skin cancer risk.

Plucked hairs can be used instead of skin biopsies to study hair traits because they contain specific cells related to hair.