Systemic Autoimmune Diseases: Insights and Advances

January 2013 in “ Clinical and developmental immunology/Clinical & developmental immunology ”

Guixiu Shi, Jianying Zhang, Zhixin Zhang, Xuan Zhang

TLDR The document concludes that systemic autoimmune diseases are complex, incurable, and require ongoing treatment and research.

The document from 2013 discusses systemic autoimmune diseases, which include conditions like rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and emphasizes their complex nature and the lack of a cure, highlighting the need for long-term treatment strategies. The special issue compiled various research papers and reviews to enhance understanding of these diseases, covering topics such as genetic and environmental factors in pathogenesis, diagnostic approaches, and treatment options. Basic research within the issue provided insights into the mechanisms of autoimmune diseases, including the role of HMGB1 in T-cell DNA demethylation, the significance of SNPs and epigenetic factors in RA, and the importance of γδ T cells in SLE. Clinical research offered clues for diagnosis and treatment, such as identifying risk factors for interstitial lung disease and evaluating the efficacy of Iguratimod in RA treatment. Reviews discussed advancements in understanding costimulatory pathways in SLE, the relationship between Epstein-Barr virus and autoimmune diseases, and the pathogenesis of alopecia areata, among other topics. Overall, the issue aimed to provide a comprehensive understanding of systemic autoimmune diseases to inform future research and clinical practice.

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