research Removing All Obstacles: A Critical Role for p53 in Promoting Tissue Renewal
The gene p53 is crucial for removing damaged cells to allow for healthy tissue renewal.
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research Topical Minoxidil Counteracts Stress-Induced Hair Growth Inhibition in Mice
Minoxidil helps prevent stress-caused hair loss in mice.
research Regulatory T Cells Are Required for Normal and Activin-Promoted Wound Repair in Mice
Regulatory T cells are essential for normal and improved wound healing in mice.
research Lichen Planus and Dyslipidemia: A Systematic Review and Meta-Analysis of Observational Studies
People with lichen planus are more likely to have dyslipidemia, especially higher triglyceride levels.
research Experimental and Thermodynamic Analyses of Supercritical CO2 Solubility of Minoxidil as an Antihypertensive Drug
Minoxidil dissolves better in propylene glycol + water than in supercritical CO2.
research Breakdown of Immune Tolerance in AIRE-Deficient Rats Induces a Severe Autoimmune Polyendocrinopathy–Candidiasis–Ectodermal Dystrophy–Like Autoimmune Disease
AIRE-deficient rats developed severe autoimmune disease similar to APECED, useful for testing treatments.
![[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) Inhibits SCF/c-kit Signaling in 501mel Human Melanoma Cells and Abolishes Melanin Production in Mice and Brownish Guinea Pigs](/images/research/4eb017dc-711d-4926-bcd0-c3b8f48e3a99/small/19974.jpg)
research [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) Inhibits SCF/c-kit Signaling in 501mel Human Melanoma Cells and Abolishes Melanin Production in Mice and Brownish Guinea Pigs
ISCK03 stops melanin production in human melanoma cells and lightens skin color in mice and guinea pigs.
research Symmetry Breaking of Tissue Mechanics in Wound-Induced Hair Follicle Regeneration of Laboratory and Spiny Mice
Tissue stiffness affects hair follicle regeneration, and Twist1 is a key regulator.
research The Antiandrogenic Effect of Finasteride Against a Mutant Androgen Receptor
Finasteride may improve prostate cancer treatment outcomes.
research Efficacy of Platelet-Rich Plasma for Treating Androgenic Alopecia of Varying Grades
Platelet-rich plasma injections significantly improve hair density and thickness in both male and female pattern hair loss, especially in early stages.
research Serum Vascular Endothelial Growth Factor B Is Elevated in Women With Polycystic Ovary Syndrome and Can Be Decreased With Metformin Treatment
Women with PCOS have higher levels of a certain growth factor, which can be reduced by taking metformin.
research Vitamin D Increases Expression of Cathelicidin in Cultured Sebocytes
Vitamin D boosts a specific protein in skin cells linked to hair follicles.
research Genetics of Structural Hair Disorders
The document concludes that over 500 genes are linked to hair disorders and this knowledge is important for creating new treatments.
research Male Androgenetic Alopecia
Male pattern baldness involves hormone-related hair thinning, shorter hair, and inflammation.
research Association of Type 2 Diabetes With Central-Scalp Hair Loss in a Large Cohort Study of African American Women
Type 2 diabetes may increase the risk of severe hair loss in African American women.
research Aesthetic Strategies for the Aging Asian Face
The document suggests using fat grafting and laser therapy to improve the aging Asian face and hair restoration techniques tailored to Asian hair characteristics, emphasizing natural results and cultural sensitivity.
research Basal Cell Carcinoma, Hedgehog Signaling, and Targeted Therapeutics: The Long and Winding Road
New treatments targeting the Hedgehog pathway can help treat advanced skin cancer but may have side effects and their effectiveness in early stages is unknown.
research Preventive Effects of Cedrol Against Alopecia in Cyclophosphamide-Treated Mice
Cedrol may prevent hair loss caused by chemotherapy better than minoxidil.
research Tooth, Hair, and Claw: Comparing Epithelial Stem Cell Niches of Ectodermal Appendages
The conclusion is that teeth, hair, and claws have similar stem cell niches, which are important for growth and repair, and more research is needed on their regulation and potential markers.
research Adam10 Haploinsufficiency Causes Freckle-Like Macules in Hairless Mice
A mutation in the Adam10 gene causes freckle-like spots on Hairless mice.
research A Missense Mutation in the P2RY5 Gene Leading to Autosomal Recessive Woolly Hair in a Syrian Patient
A gene mutation causes woolly hair in a Syrian patient.
research Status of Medical Treatment for Androgenetic Alopecia
Minoxidil effectively promotes hair regrowth in younger patients with small balding areas.
research Mechanisms of Tolerance and Potential Therapeutic Interventions in Alopecia Areata
Targeting immune tolerance issues in Alopecia Areata could restore hair growth and maintain remission.
research Metabolic Dysfunction in Female Mice with Disruption of 5α-Reductase 1
Female mice with disrupted 5α-reductase 1 had significant metabolic issues, including stress response problems, insulin resistance, liver fat buildup, and obesity.
research Antroquinonol Exerts Immunosuppressive Effect on CD8+ T Cell Proliferation and Activation to Resist Depigmentation Induced by H2O2
Antroquinonol may help prevent skin depigmentation by suppressing certain immune cells.
research A Functional Polymorphism in Interleukin-1α (IL1A) Gene Is Associated with Risk of Alopecia Areata in Chinese Populations
A certain genetic variation in the IL1A gene may lower the risk of a hair loss condition in Chinese people.
research Unraveling the Link Between Ectodermal Disorders and Primary Immunodeficiencies
Skin abnormalities can indicate immunodeficiency due to shared origins with the immune system.
research First Symposium on Natural Gene Therapy of the Skin
Natural gene therapy shows promise for treating skin disorders like epidermolysis bullosa.
research Molecular Evolution of HR, a Gene That Regulates the Postnatal Cycle of the Hair Follicle
Changes in the HR gene have influenced hair growth and may lead to hair loss conditions in humans.
research Lentiginosis Within Plaques of Linear Atrophoderma of Moulin: A Twin-Spotting Phenomenon?
The document suggests a rare skin condition might be caused by a genetic phenomenon.