12 citations
,
August 2020 in “Frontiers in Genetics” This study suggests that the long noncoding RNA H19 helps dermal papilla cells maintain their hair follicle-inducing ability by activating the Wnt signaling pathway, potentially offering a therapeutic target for androgenetic alopecia.
10 citations
,
July 2011 in “British Journal of Dermatology” This study found that brain-derived nerve factor protein expression was significantly increased in balding scalp samples from men with androgenetic alopecia, suggesting it may play a role in hair follicle regulation.
8 citations
,
April 2009 in “International journal of oncology” This study found that bulge-derived keratinocytes from human follicles were more resistant to differentiation compared to epidermal keratinocytes, possibly due to WIF-1 involvement.
8 citations
,
June 2019 in “Scientific Reports” This study found that the retinoid receptor and PPAR pathway are involved in hair follicle miniaturization in androgenetic alopecia, alongside androgen receptors.
7 citations
,
January 2015 in “Current problems in dermatology” This chapter reviews common drug-related and systemic disorder-induced alopecias, focusing on their epidemiology, causes, symptoms, diagnosis, and treatment, but reports no new findings.
6 citations
,
April 2017 in “Frontiers in Pharmacology” This study found that several compounds from Yangxue Shengfa capsule may promote hair growth by enhancing cell proliferation in vitro, suggesting potential use in treating androgenetic alopecia.
5 citations
,
January 2012 in “Biological & Pharmaceutical Bulletin” This study found that extract of Hura crepitans inhibited androgen-accelerated NT-4 activity and ameliorated the retardation of hair regrowth in dihydrotestosterone-implanted mice, suggesting a potential role for NT-4 inhibitors in AGA.
5 citations
,
September 2020 in “Molecules” In this study, extracts from three Polynesian plants—Bidens pilosa, Calophyllum inophyllum, and Fagraea berteroana—were found to increase dermal papilla cell proliferation and modulate hair growth-related gene expression, suggesting potential for stimulating hair growth.
5 citations
,
January 2016 in “Journal of Molecular Histology” Both main and alternative Wnt signaling are important for regrowing rodent whisker follicles.
3 citations
,
June 2020 in “Developmental Cell” This study observed that in chicken skin, large-scale differences in gene expression between feathered and scaly skin are controlled by enhancer-driven uniform expression, while small-scale differences within individual feathers are associated with chromatin looping.
1 citations
,
July 2024 in “Syntax Literate Jurnal Ilmiah Indonesia” In this study, topical application of 5% minoxidil significantly increased hair follicle density in a mouse model of androgenetic alopecia, as evidenced by a rise in density from 24.00 in the control group to 40.14 in the treatment group.
June 2026 in “Jurnal Pendidikan Tambusai” This study observed that 61.3% of helmets from online motorcycle taxi passengers in the Stasiun Tugu Yogyakarta area were contaminated with dermatophyte fungi, with higher contamination risk in helmets used over five years or infrequently cleaned.
December 2024 in “JAPI (Jurnal Akses Pengabdian Indonesia)” This study found that a community education program using group discussions and leaflets significantly increased knowledge and skills among Sungai Bilu residents in South Kalimantan for using riverbank plants as alternative medicine.
August 2024 in “Scholars Journal of Applied Medical Sciences” This study found that combining platelet-rich plasma therapy with minoxidil significantly improved hair growth and hair follicle cell proliferation in men with androgenetic alopecia compared to either treatment alone.
July 2024 in “Jurnal Pengabdian Masyarakat Putri Hijau” This study involved educating Dewantara Husada Health Vocational High School students about using meniran leaf extract in pomade formulations as a hair growth stimulant, demonstrating high engagement and interest in the topic.
October 2023 in “Scientific reports” In this study, researchers found that the synthetic stress hormone dexamethasone caused opposite effects on hair growth-related proteins, reducing SFRP2 and increasing SFRP3, which respectively stimulate and inhibit hair follicle cell proliferation in human dermal papilla cells.
June 2023 in “Journal of Pharmaceutical and Health Research” In this study with guinea pigs, a hair tonic containing 0.001% caffeine significantly stimulated hair growth, showing higher effectiveness with an average hair length of 18.294 mm compared to a tonic with 0.005% caffeine concentration, which resulted in an average hair length of 16.610 mm.
October 2021 in “VITEK Bidang Kedokteran Hewan” This case study reports on a 1-year-old male goat with various health issues including bloody stool, hair loss, and lice, treated with medication and supplements.
This study reports that in Rex rabbits, age affects fur quality and hair follicle traits, with the Wnt signaling pathway playing a role in their periodic hair follicle development.
September 2019 in “Journal of Investigative Dermatology” This study introduced a reproducible human model using 3D-SeboSkin technology to study hidradenitis suppurativa, allowing better maintenance of skin integrity and replication of biomarker expression patterns compared to traditional skin cultures, suggesting its value for further research.
October 2003 in “Journal of Investigative Dermatology Symposium Proceedings” Mice treatments didn't grow hair, a patient treatment may affect immune response, and people with hair loss often feel anxious or depressed.
1533 citations
,
October 2008 in “Endocrine reviews” This research highlights that engineered mice lacking the vitamin D receptor show multiple health issues similar to human vitamin D deficiency, underscoring the widespread impacts of the vitamin D endocrine system.
1039 citations
,
February 2009 in “Nature Reviews Molecular Cell Biology” This review discusses the reuse of molecular mechanisms involved in embryonic skin development for maintaining adult epidermal homeostasis and reports no new results.
829 citations
,
May 2007 in “Nature” Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.
788 citations
,
February 2007 in “Nature” This review explores how adult skin epithelia preserve stem cell populations for hair follicle regeneration and wound healing, but reports no new experimental results.
759 citations
,
February 2009 in “Current Biology” This review summarizes fundamental concepts and recent advancements in hair follicle biology, including insights from mouse models into broader molecular and cellular processes relevant to regeneration and development.
556 citations
,
September 2008 in “Genes & Development” This review summarizes how genetic studies using conditional β-catenin loss- and gain-of-function mice have advanced understanding of canonical Wnt signaling's role in embryonic development, adult stem cell maintenance, and cancer modeling.
508 citations
,
February 2007 in “Cell” This article reviews the biology of epithelial stem cells and their role in tissue self-renewal, maintenance, and regeneration, and it highlights the clinical implications of understanding their signaling pathways, but it presents no new clinical findings.
471 citations
,
October 2012 in “Cellular and Molecular Life Sciences” This review discusses the roles of key developmental signaling pathways in mammalian skin repair compared to skin development, and suggests these insights could lead to better wound healing therapies, but it reports no new findings.
417 citations
,
September 2005 in “PLoS biology” This study developed molecular signatures for dermal papilla cells and their niche, uncovering novel signaling regulators and genes linked to hair disorders, which may inform future hair development research.