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The new chemotherapy combination for advanced lung cancer showed a 35.7% response rate but caused significant side effects.

In this study, a UK expert panel discussed strategies for managing common side effects of vismodegib, a hedgehog pathway inhibitor used for advanced basal cell carcinoma, concluding that adverse events like taste disturbances and muscle cramps can be effectively managed to optimize treatment duration.

This review discusses three classes of thiazole-bearing compounds in drug development and presents preclinical findings but reports no new experimental results, highlighting the need for further drug discovery.

This article reviews clinical issues and dermatologist perspectives on managing periungual lesions in patients undergoing docetaxel chemotherapy, but it reports no new clinical outcomes.

In this mouse study, topical 1,25-dihydroxyvitamin D3 protected against cyclophosphamide-induced hair loss and inhibited mammary tumor growth, with effects varying by sex and tumor presence.

This review in SEDA Volume 40 summarizes new adverse reaction data for diuretics published in 2017, highlighting specific risks such as fractures with loop diuretics and hyperkalemia with spironolactone.

This case report describes a 55-year-old woman who experienced transient hair loss possibly linked to the start of dimethyl-fumarate therapy for relapsing-remitting Multiple Sclerosis.

Mycophenolate mofetil improved skin condition in a man with nephrogenic fibrosing dermopathy.

In this study, two methotrexate-loaded liquid crystal formulations for topical application showed immunomodulatory effects and induced skin changes in mice with imiquimod-induced psoriasis.

This study concluded that Metformin may be suitable for prophylaxis or mild COVID-19, while a combination of Oseltamivir, Tamoxifen, and Dexamethasone could benefit moderate to severe cases, highlighting the need for more trials on other drug candidates.

This scoping review investigates cases of toxic minoxidil exposure in cats and dogs, detailing their clinical presentations, management strategies, and outcomes, without reporting specific results.

This study in female beagle dogs found that long-term exposure to oral contraceptive steroids resulted in significant reproductive and mammary gland changes, with the relevance to human tumor risk remaining uncertain.

In this study, a single application of a 10 mg/mL deltamethrin-based solution effectively reduced lice infestations by 98% to 100% in treated horses and prevented new infestations for up to a month, without adverse events reported.

This study found that both tofacitinib and methotrexate effectively reduced hair loss and psychological distress in patients with moderate-to-severe alopecia areata, but tofacitinib showed much greater efficacy. Both treatments had similar safety profiles, with no serious adverse effects reported.

This phase I study determined that a combination of oral SU-014813 and docetaxel is a feasible treatment with a manageable safety profile and potential anti-tumor activity, particularly noted in melanoma and GIST patients.

This study found that formulating raloxifene in nano-lipid carriers significantly enhanced its permeation and cytotoxicity against cancer cells compared to raw raloxifene.

This study found that type 2 diabetes mellitus does not affect the pharmacokinetics of metformin in obese pregnant women with PCOS, suggesting no need for dosage adjustments.

This study found that diphlorethohydroxycarmalol significantly increased prostaglandin $E_2$ synthesis in HaCaT human keratinocytes by upregulating COX-1 and COX-2 expression, suggesting potential benefits from elevated $PGE_2$ production.

This study found that 29.4% of patients treated with methotrexate for non-hair-related conditions experienced increased hair loss, with more frequent reports among women.

This study found that ozonated olive oil exhibited antifungal activity against Trichophyton mentagrophytes, comparable to the standard antifungal terbinafine, in an in vivo rat study, suggesting it may serve as an alternative treatment for dermatophytosis.

In this pilot study, both tofacitinib and methotrexate improved alopecia areata outcomes, but tofacitinib showed greater efficacy in achieving significant SALT score improvement after 6 months, although the difference was not statistically significant.

This study found that applying a hair mist with dandelion extract before heat perming improved wave efficiency, tensile strength, and hair cuticle condition compared to a base mist or no pretreatment, demonstrating the extract's protective effects against heat damage.

This study found that both topiramate and divalproex sodium were similarly effective in reducing headache frequency by over 50% among episodic migraine patients after three months of treatment.

In this pilot study, researchers found that ex vivo treatment with topical melatonin reduced chemotherapy-induced apoptosis and DNA damage in hair follicle stem cells of human scalp cultures, suggesting melatonin's potential as a protective agent against taxane-induced permanent hair loss.

In this study, PEGDE above 10,000 μg/mouse caused subcutaneous toxicity including ulceration in mice, but did not affect liver, spleen, or kidney tissues.

This study found that microemulsion and microemulsion-based hydrogels may offer a more effective and sustained topical delivery method for minoxidil compared to conventional solutions for hair loss treatment.

This study identified new oxidative derivatives of finasteride, including a newly discovered metabolite, by using the fungus Macrophomina phaseolina.

This study found that using spanlastics, a nano, surfactant-based drug delivery system, improved the bioavailability, drug release characteristics, and pharmacokinetic behavior of famotidine, a poorly soluble drug, by enhancing its dissolution and membrane permeation.

This study developed a new permanganometric method for determining minoxidil in pharmaceutical formulations, offering a simple and rapid alternative to chromatographic procedures with recovery rates between 94.5% and 95.2%.