Innovative Sequence of Docetaxel–Gemcitabine Based on Preclinical Data in the Treatment of Advanced Non-Small Cell Lung Cancer: A Phase I Study

    February 2005 in “ Lung Cancer ”
    Toni Ibrahim, Wainer Zoli, Giovanni Luca Frassineti, Anna Tesei, I. Colantonio, Manuela Monti, Dino Amadori
    Image of study
    TLDR The new chemotherapy combination for advanced lung cancer showed a 35.7% response rate but caused significant side effects.
    In a 2005 phase I study, researchers assessed a new chemotherapy regimen combining docetaxel (DOC) and gemcitabine (GEM) in 15 patients with stage IIIB-IV non-small cell lung cancer (NSCLC). The treatment involved administering DOC on day 1 and GEM on days 3 and 8, every 21 days, with dose escalation to determine the maximum tolerated dose (MTD). The study was halted at the fifth dose level due to significant toxicities, including grade 4 febrile neutropenia. Neutropenia was the most common adverse effect, and other side effects included diarrhea, nausea, vomiting, mucositis, and alopecia. Out of 14 evaluable patients, there was one complete response, four partial responses, four stable diseases, and five disease progressions. The overall response rate was 35.7%, and a phase II trial was planned using the fourth dose levels.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Alopecia Areata Question

      in Treatment  2 upvotes 3 years ago
      A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

      community mbp alopecia areata or vitamin deficiency

      in Chat 4 months ago
      A 19-year-old male has been using topical finasteride and minoxidil for 8 months with no progress and is considering seeking a second opinion due to potential misdiagnosis. The discussion revolves around whether the hair loss is due to male pattern baldness, alopecia areata, or a vitamin deficiency.

      community Androgenic alopecia exclusively on the vertex of the scalp

      in Chat  6 upvotes 6 months ago
      A user experienced androgenic alopecia starting at the vertex without frontal hairline recession and is seeking information on this pattern. Another user noted that vertex or diffuse hair loss is common among men.

      community Fibrosing alopecia in a pattern distribution

      in Research/Science  14 upvotes 8 months ago
      A user has been experiencing hair loss for 4 years, with treatments like minoxidil, finasteride, and various supplements proving ineffective. They were diagnosed with fibrosing alopecia in a pattern distribution, a condition that may require a combination of anti-inflammatory and hair growth treatments.

      community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

      in Research/Science  65 upvotes 1 year ago
      Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

    Similar Research

    6 / 1000+ results