The Successful Treatment of Nephrogenic Fibrosing Dermopathy with Mycophenolate Mofetil

The document reports on a case where a 56-year-old man with end-stage renal failure developed nephrogenic fibrosing dermopathy (NFD), a condition characterized by painful, itchy legs with thickened skin plaques. He was treated with prednisolone and mycophenolate mofetil (MMF), which led to improved pain and mobility, and after 3 months, his skin had softened. Despite this improvement, he still experienced pruritus, which was then successfully reduced with narrowband ultraviolet B phototherapy. This case is significant as it is the first reported positive response to immunosuppressant therapy for NFD, a condition that has been associated with various potential causes, including infectious agents or toxins triggering fibrogenesis. The patient's response to MMF is particularly interesting given that other patients have developed NFD while on MMF for graft rejection, suggesting a multifactorial etiology for NFD.