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This research found that inhibiting HSP90 in a murine model increased cellular plasticity, suggesting a potential role for HSP90 in cancer progression through enhanced adaptability to stress.

This study found that Ishige sinicola extract stimulated osteoblast differentiation and bone formation in MC3T3-E1 cells, suggesting potential use for osteoporosis prevention and treatment.

This study suggests that 5α-reductase-mediated metabolism of progesterone contributes to the differentiation of endometrial stromal cells, potentially influencing progesterone levels and promoting cell differentiation.

This study found that heparanase is primarily located in the inner root sheath of human hair follicles during the anagen phase, and inhibiting it in cultured hair follicles induces a catagen-like process.

In this study, researchers developed two novel mouse models to investigate how CD271 deletion in keratinocytes affects skin homeostasis, finding that it leads to changes resembling dysplastic skin conditions with immune cell recruitment and inflammatory cytokine release.

This study suggests that Artemis, particularly phosphorylated at serine 516, may have roles in hair follicle growth by influencing differentiation, proliferation, apoptosis, and cell cycling.

This study found that the p63 transcription factor is expressed during rat epidermal development and may serve as a specific marker for keratinocyte progenitor cells.

This study found that BMPs can counteract the inhibitory effects of androgens on hair follicle stem cell differentiation, highlighting their critical role in the pathway dysregulation seen in androgenetic alopecia.

In this study, YK11 was found to promote osteoblast cell proliferation and differentiation through activation of non-genomic signaling pathways in mouse osteoblast cells.

This study found that treating hair follicular stem cells with tissue extract from 10-day-old mouse embryos significantly enhanced their differentiation into neural cells, particularly with higher extract concentrations.

Stem cells are in deep skin layers, while differentiating cells are in shallow layers.

This article discusses the development and research applications of human hair follicle organ culture techniques, highlighting its potential to explore biological processes beyond dermatology.

This study explored the use of "microfollicles," a human hair follicle organoid model, as an in vitro tool for testing hair-growth substances, finding up to 75% overlap in gene expression changes with human clinical biopsy responses to minoxidil, indicating its potential for pre-clinical substance testing.

This study found that IBA-1-immunopositive macrophages in rat skin during wound healing show varied morphometric characteristics and peak in numbers at 2, 6, and 15 days post-injury.

This study identified a distinct CD49fhigh mesenchymal stem cell subpopulation in the dermis that supports hair follicle development and maintenance via Notch signaling activation.

This study found that the combination of TTNPB and CHIR99021 enhanced the derivation of highly advanced neural stem cells from human pluripotent stem cells, with improved chromatin accessibility and neuroectodermal gene expression, and these cells successfully engrafted in rat hippocampi to ameliorate depression-like symptoms.

This review discusses the regulation of involucrin gene expression, focusing on transcription factors and signaling pathways, and reports no new experimental findings.

This study found that treating skin wounds with a combination of epidermis-derived epithelial-like stem/progenitor cells and platelet-rich plasma improved tissue repair and increased vascularization and elastin content compared to platelet-rich plasma alone.

This study found that melanocyte progenitor cells are present in human subcutaneous adipose tissue and may differentiate into mature melanocytes, suggesting potential applications in treating skin diseases and rejuvenation.

This review discusses the characteristics and potential applications of epidermal stem cells in dermatology, without providing new clinical results.

This study found that wounding in skin induces significant fibroblast heterogeneity and recruits myeloid cells, which contribute to adipocyte regeneration in mice.

Adult hair follicle cells can create new hair follicles from corneal cells with the right support.

In this study, BLIMP1 was found to function in terminally differentiated epidermal cells to maintain homeostasis, rather than defining a sebocyte progenitor population.

This study found that transgenic mice expressing human keratin K8 in the epidermis showed increased progression of skin lesions toward malignancy, suggesting a role for K8 in the development of invasive skin cancer.

This study introduces a spherical skin model that effectively mimics key features of human skin, offering a scalable and rapid alternative for non-animal dermatological and cosmetic testing.

This study demonstrated that an engineered human skin equivalent can generate follicle-like structures resembling fetal skin, highlighting the role of the dermal compartment in directing epithelial cell fate in vitro.

This review discusses the roles of filaggrin and trichohyalin in keratinocyte differentiation and reports no new results; the authors introduce possible hybrid granules in tongue epithelia.

In this study, researchers explored the heterogeneity of pigment cells in the human scalp anagen hair follicle bulb and discovered unexpected subpopulations of melanocytes, including immature SOX10-negative cells, highlighting potential non-melanogenic roles or transitional migratory functions that require further investigation.

This guide reviews the biology of sebaceous glands and their evaluation methods, emphasizing their roles beyond lipid production in skin health and disease, and reports no new research results.

Human hair follicles can be used to create skin-like tissue for wound healing and drug testing.