18 citations
,
October 2017 in “PLOS ONE” This study found that in Pomeranians with Alopecia X, key genes in the Wnt and Shh signaling pathways and stem cell markers are downregulated, which may explain the absence of anagen hair follicles.
15 citations
,
January 2008 in “Actas Dermo-Sifiliográficas” This study found that immunohistochemistry for calretinin may identify certain cutaneous adnexal tumors with follicular differentiation towards cells of the outer root sheath.
13 citations
,
September 2016 in “Journal of Cellular Biochemistry” This study found that under hypoxic conditions, hair follicle-associated pluripotent stem cells differentiated into cardiac muscle cells at a higher rate compared to normoxic conditions.
12 citations
,
May 2013 in “International Journal of Molecular Sciences” In this study, researchers isolated multipotent stem cells from elderly human epidermis and showed that they could differentiate into neurons using TAT-VHL peptide, suggesting potential for regenerative therapies.
11 citations
,
February 2021 in “Frontiers in Bioengineering and Biotechnology” This study suggests that short-term treatments with specific small molecules may enhance the differentiation potential and stem cell properties of human amniotic fluid stem cells.
6 citations
,
June 2021 in “Developmental biology” This study found that dermal EZH2 plays a crucial role in controlling fibroblast differentiation by regulating Wnt/β-catenin and retinoic acid signaling during skin development.
3 citations
,
December 2007 in “Journal of Otology” This study found that adipose-derived stem cells from adult guinea pigs can differentiate into hair cell-like cells in vitro, suggesting potential use in tissue engineering.
2 citations
,
February 2017 in “International Journal of Molecular Sciences” This study found that Erdr1 expression was significantly reduced in the skin of patients with hair loss disorders, particularly alopecia areata, suggesting it may serve as a novel biomarker.
2 citations
,
August 2013 in “Journal of Investigative Dermatology” This review discusses the dynamic changes in chromatin organization and nuclear morphology during cellular processes like differentiation and disease, highlighting recent advances in understanding these epigenetic mechanisms without presenting new experimental findings.
November 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that mature adipocytes can dedifferentiate into fibroblast-like cells, driven by PDGF and TGFβ signaling, which may play a role in wound repair and fibrosis.
September 2016 in “Journal of dermatological science” The researchers reported that the OVOL1-OVOL2 axis may play a role in hair follicle differentiation and tumorigenesis, and OVOL1 and OVOL2 are potential diagnostic markers for pilomatricoma and pilomatrix carcinoma.
January 2010 in “Zhongguo xiandai yixue/Zhongguo xiandai yixue zazhi” This study found that epithelial stem cells from umbilical skin can differentiate into various cell types, suggesting potential roles in epidermis and hair cell formation.
17 citations
,
April 2017 in “PLoS ONE” This study found that neural crest-derived hair follicle cells in mice can differentiate into osteoblast-like cells, suggesting a potential application for bone regenerative therapies.
2 citations
,
August 2023 in “Molecules” This study found that a quinazoline derivative, SH-340, increased skin barrier-associated factors and inhibited TSLP expression and STAT6 phosphorylation in human primary keratinocytes, suggesting potential benefits for alleviating inflammation and improving skin barrier function in atopic dermatitis.
143 citations
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October 2008 in “Journal of The American Academy of Dermatology” This study found that comma hairs are a distinctive feature of tinea capitis caused by Microsporum canis, distinguishing it from alopecia areata, which is characterized by exclamation mark hairs.
26 citations
,
May 2011 in “Tissue Engineering Part A” This study found that mouse embryoid bodies adhered quickly and differentiated efficiently into cardiomyocytes on negatively charged poly(sodium p-styrene sulfonate) hydrogels, similar to their behavior on gelatin-coated polystyrene.
19 citations
,
September 2013 in “Molecular Medicine Reports” In this study, researchers developed a method to efficiently derive contractile smooth muscle cells from human hair follicle stem cells using TGF-β1 and PDGF-BB, which may advance vascular tissue engineering.
14 citations
,
January 2020 in “Research Journal of Pharmacy and Technology” This study found that mesenchymal stem cells from adipose tissue and hair follicles have a similar ability to differentiate into neurons, which could aid in developing therapies for neurological diseases.
2 citations
,
October 2017 in “PubMed” This study found that serum bone metabolic markers with mild changes are interdependently related to traditional Chinese medicine syndromes in patients with chronic kidney disease-related bone disorders.
This study reported that rapamycin reduced murine cochlear organoid proliferation depending on concentration, but at a 10-nM dose, it significantly increased hair cell differentiation by enriching SOX2+ progenitors while suppressing cells lacking Sox2 at early proliferation stages.
1 citations
,
February 2002 in “The Lancet” Keratinocytes might turn into stem cells, but more research is needed to confirm this.
7 citations
,
June 2017 in “Journal of Cutaneous Pathology” This study reports a case of cystic panfolliculoma, highlighting the role of epithelial-mesenchymal interactions in its pathogenesis and explaining its histological resemblance to trichofolliculoma.
11 citations
,
June 2019 in “Tissue & Cell” This study indicates that COL17A1 plays a crucial role in the differentiation process of hair-follicle-associated pluripotent stem cells.
1 citations
,
January 2010 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found that 0.5μg/ml silibinin significantly promoted the differentiation of hair follicle stem cells into neurons, while higher concentrations were toxic and lower ones had no effect.
May 2012 in “DOAJ (DOAJ: Directory of Open Access Journals)” In this study, silibinin at 0.5 μg/ml significantly promoted hair follicle stem cell differentiation into neurons in rats, while higher concentrations were toxic.
April 2026 in “Research Square” In this study, trichoscopic examination revealed that variations in hair diameter were more common in certain types of alopecia affecting the frontal scalp, suggesting the importance of evaluating the entire scalp for accurate diagnoses, although limitations include a single center design and small sample size.
35 citations
,
December 2008 in “PubMed” In this study, researchers reported that specific immunoreactivity patterns observed in hair follicle stem cell markers suggest different origins for trichilemmoma, basal cell carcinoma, and squamous cell carcinoma in human skin tissues.
5 citations
,
January 2018 in “Indian Dermatology Online Journal” This case report describes a strong dermoscopic and histopathological correlation in lichen nitidus, helping differentiate it from other similar conditions.
1 citations
,
May 2022 in “Reproductive Endocrinology” This review discusses the complexities of diagnosing and managing hyperandrogenism in women, emphasizing the need for careful evaluation of both clinical signs and biochemical markers without reporting new clinical results.
37 citations
,
April 2013 in “PLoS ONE” In this study, the researchers found that thymosin beta-4 promotes odontoblastic differentiation in human dental pulp cells, suggesting it as a potential mechanism for regenerative endodontics.